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Literature DB >> 3987713

Acute and chronic effects of carbamyl glutamate on blood urea and ammonia.

Abstract

Carbamyl glutamate injected into normal rats produced no change in blood urea levels. Rats fed a high-protein diet or starved for 48 h had increased blood urea. Carbamyl glutamate injection induced a further increase in the levels of urea in their blood. Also, carbamyl glutamate administered in the drinking water of normal mice produced an increase in blood urea, which was accompanied by a decrease in blood ammonia. The application of these findings to the treatment of urea cycle enzymopathies is discussed.

Entities: Chemical Disease Species

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Year: 1985 PMID： 3987713 DOI： 10.1007/bf00442137

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

7 in total

1. Catalytic rôle of of glutamate derivatives in citrulline biosynthesis.

Authors: S GRISOLIA; P P COHEN
Journal: J Biol Chem Date: 1953-10 Impact factor: 5.157

2. On benzoate therapy for ammonia toxicity.

Authors: C C Tremblay; P A Wendler
Journal: Pediatrics Date: 1982-09 Impact factor: 7.124

3. Potentiation of hyperammonemia by sodium benzoate in animals. A note of caution.

Authors: J E O'Connor; M Ribelles; S Grisolia
Journal: Eur J Pediatr Date: 1982-03 Impact factor: 3.183

4. N-acetylglutamate synthetase deficiency: a disorder of ammonia detoxication.

Authors: C Bachmann; S Krähenbühl; J P Colombo; G Schubiger; K H Jaggi; O Tönz
Journal: N Engl J Med Date: 1981-02-26 Impact factor: 91.245

5. Ammonia intoxication in rats: protection by N-carbamoyl-L-glutamate plus L-arginine.

Authors: S Kim; W K Paik; P P Cohen
Journal: Proc Natl Acad Sci U S A Date: 1972-12 Impact factor: 11.205

6. The relationship between intramitochondrial N-acetylglutamate and activity of carbamoyl-phosphate synthetase (ammonia). The effect of glucagon.

Authors: H E Hensgens; A J Verhoeven; A J Meijer
Journal: Eur J Biochem Date: 1980

7. Induction of urea cycle enzymes of rat liver by glucagon.

Authors: P J Snodgrass; R C Lin; W A Müller; T T Aoki
Journal: J Biol Chem Date: 1978-04-25 Impact factor: 5.157

7 in total

8 in total

1. Therapeutic use of carbamylglutamate in the case of carbamoyl-phosphate synthetase deficiency.

Authors: G Kuchler; D Rabier; F Poggi-Travert; D Meyer-Gast; J Bardet; V Drouin; M Cadoudal; J M Saudubray
Journal: J Inherit Metab Dis Date: 1996 Impact factor: 4.982

2. N-carbamylglutamate enhancement of ureagenesis leads to discovery of a novel deleterious mutation in a newly defined enhancer of the NAGS gene and to effective therapy.

Authors: Sandra K Heibel; Nicholas Ah Mew; Ljubica Caldovic; Yevgeny Daikhin; Marc Yudkoff; Mendel Tuchman
Journal: Hum Mutat Date: 2011-09-09 Impact factor: 4.878

3. N-acetylglutamate synthetase deficiency: diagnosis, management and follow-up of a rare disorder of ammonia detoxication.

Authors: G Schubiger; C Bachmann; P Barben; J P Colombo; O Tönz; D Schüpbach
Journal: Eur J Pediatr Date: 1991-03 Impact factor: 3.183

8. Potential role of N-carbamoyl glutamate in biosynthesis of arginine and its significance in production of ruminant animals.

Authors: Bahram Chacher; Hongyun Liu; Diming Wang; Jianxin Liu
Journal: J Anim Sci Biotechnol Date: 2013-04-10