Literature DB >> 3986538

On the origin of dopamine and its metabolite in predominantly noradrenergic innervated brain areas.

B H Westerink, J B de Vries.   

Abstract

The origin of dopamine (DA) and its metabolite in predominantly noradrenergic brain areas was investigated in rats with a unilateral electrolytic lesion of the locus coeruleus. Using the unlesioned side as a control, levels of DA, noradrenaline (NA), and the DA metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), were measured in lateral hippocampus, cerebellum, frontal cortex, occipital cortex, brainstem and striatum. Lesion of the locus coeruleus decreased brain NA levels in those regions innervated by this nucleus, but had no effect on levels of DA and DOPAC in any of the regions studied. It is concluded that even in regions of very low DA concentration, DA and DOPAC probably originate from dopaminergic neurons rather than via NA formation in noradrenergic neurons.

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Year:  1985        PMID： 3986538     DOI： 10.1016/0006-8993(85)90020-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

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2.  Effect of aging on dopamine metabolism in the rat cerebral cortex: a regional analysis.

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9.  ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment.

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  9 in total

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