Literature DB >> 3986313

High affinity GDP binding sites on brown adipose tissue mitochondria of genetically obese 'fa/fa' rats.

R R French, S J Holt, D A York.   

Abstract

The number of high affinity [3H]GDP binding sites in brown adipose tissue mitochondria is normal in obese (fa/fa) rats in contrast to the reduced number of low affinity GDP binding sites. Adrenalectomy corrected the loss of low affinity binding sites in fa/fa rats but had no effect on the number of high affinity sites in either lean or obese rats. Equilibrium dialysis was used to show the presence of both high and low affinity binding sites on the purified 32 kdalton protein.

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Year:  1985        PMID: 3986313     DOI: 10.1007/bf01117062

Source DB:  PubMed          Journal:  Biosci Rep        ISSN: 0144-8463            Impact factor:   3.840


  4 in total

1.  Regulation of GDP binding and uncoupling-protein concentration in brown-adipose-tissue mitochondria. The effects of cold-acclimation, warm-reacclimation and noradrenaline.

Authors:  T Peachey; R R French; D A York
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

2.  A study of GDP binding to purified thermogenin protein from brown adipose tissue.

Authors:  R R French; M G Gore; D A York
Journal:  Biochem J       Date:  1988-04-15       Impact factor: 3.857

3.  Evidence for unmasking of rat brown-adipose-tissue mitochondrial GDP-binding sites in response to acute cold exposure. Effects of washing with albumin on GDP binding.

Authors:  C L Gribskov; M F Henningfield; A G Swick; R W Swick
Journal:  Biochem J       Date:  1986-02-01       Impact factor: 3.857

4.  Acute effects of a beta-adrenoceptor agonist (BRL 26830A) on rat brown-adipose-tissue mitochondria. Increased GDP binding and GDP-sensitive proton conductance without changes in the concentration of uncoupling protein.

Authors:  R E Milner; S Wilson; J R Arch; P Trayhurn
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

  4 in total

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