Literature DB >> 3983644

Ethanol neurotoxicity: effects on neurite formation and neurotrophic factor production in vitro.

K E Dow, R J Riopelle.   

Abstract

The effects of ethanol on chick embryo sensory and spinal cord neurons growing on one of several biological substrates (poly-D-lysine, laminin, or neuron-produced neurite-promoting materials) were examined. Ethanol inhibited process formation by the neurons in a dose-dependent manner and inhibited the production of neurotrophic factors. Neuronal attachment to the substrates, survival of attached neurons, and receptor interactions of sensory neurons with nerve growth factor were not influenced by ethanol. It appears that ethanol alters certain metabolic characteristics of developing neurons.

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Year:  1985        PMID： 3983644     DOI： 10.1126/science.3983644

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  13 in total

1.  Ethanol inhibits L1-mediated neurite outgrowth in postnatal rat cerebellar granule cells.

Authors:  C F Bearer; A R Swick; M A O'Riordan; G Cheng
Journal:  J Biol Chem       Date:  1999-05-07       Impact factor: 5.157

Review 2.  A paradigm for examining toxicant effects on viability, structure, and axonal transport of neurons in culture.

Authors:  D J Brat; S Brimijoin
Journal:  Mol Neurobiol       Date:  1992 Summer-Fall       Impact factor: 5.590

3.  Effects of ethanol on rat Schwann cell proliferation and myelination in culture.

Authors:  F A Mithen; M M Reiker; R Birchem
Journal:  In Vitro Cell Dev Biol       Date:  1990-02

4.  The effects of ethanol on embryonic actin: a possible role in teratogenesis.

Authors:  J A Hassler; D J Moran
Journal:  Experientia       Date:  1986-05-15

5.  Influence of N-linked oligosaccharides on the processing and neurite-promoting activity of proteoglycans released by neurons in vitro.

Authors:  K E Dow; R J Riopelle
Journal:  Cell Tissue Res       Date:  1992-06       Impact factor: 5.249

6.  Neurotrophin ligand-receptor systems in somatosensory cortex of adult rat are affected by repeated episodes of ethanol.

Authors:  Marla B Bruns; Michael W Miller
Journal:  Exp Neurol       Date:  2007-01-08       Impact factor: 5.330

7.  Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression.

Authors:  Y Y Xu; K Bhavani; J R Wands; S M de la Monte
Journal:  Biochem J       Date:  1995-08-15       Impact factor: 3.857

8.  Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.

Authors:  Suzhen Chen; Michael E Charness
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-01       Impact factor: 11.205

Review 9.  Fetal alcohol syndrome: the vulnerability of the developing brain and possible mechanisms of damage.

Authors:  J R West; W J Chen; N J Pantazis
Journal:  Metab Brain Dis       Date:  1994-12       Impact factor: 3.584

10.  Ethanol alters astrocyte development: a study of critical periods using primary cultures.

Authors:  C Guerri; R Sáez; M Sancho-Tello; E Martin de Aquilera; J Renau-Piqueras
Journal:  Neurochem Res       Date:  1990-05       Impact factor: 3.996
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