| Literature DB >> 3983140 |
R M Millis, J D Barber, W A Anderson, A J Gold, C B Storm, C A Reindorf.
Abstract
Perfusion of isolated kidneys from rats demonstrated the following nephrotoxic effects of Fluosol-DA: decreased glomerular filtration rate (GFR), urine flow rate (UFR), and fractional reabsorption of potassium (FrK+) (P less than 0.01). Fluosol-DA perfusions were at flow rates about equal to the physiologically normal rodent renal plasma flow rate of 4 ml/min. Stroma-free hemoglobin (SFH) perfusions, also at 4 ml/min, were associated with physiologically normal renal functions, as were those of control Krebs-Ringer bicarbonate (KRB) perfusions at 32 ml/min.Entities:
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Year: 1985 PMID： 3983140 DOI： 10.3181/00379727-178-4-rc1
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727