Literature DB >> 3982648

Acetylcholine receptor antibody production by bone marrow cells in a patient with myasthenia gravis.

Y Fujii, Y Monden, J Hashimoto, K Nakahara, Y Kawashima.   

Abstract

We briefly report antiacetylcholine receptor antibody production by cultured bone marrow cells (4.9 +/- 0.9 fmol/10(6) cells/wk, mean +/- SD) in a 65-year-old man with myasthenia gravis without thymoma. Lymphocytes from peripheral blood, thymus, and lymph nodes produced less antibody (1.8 +/- 0.1, 0.9 +/- 0.3, and 1.0 +/- 0.4, respectively). The thymus was involuted, and the effect of thymectomy was doubtful 6 months postoperatively.

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Year:  1985        PMID： 3982648     DOI： 10.1212/wnl.35.4.577

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  9 in total

1.  Measurement of antiacetylcholine receptor antibody in patients with thymoma without myasthenia gravis complications.

Authors:  M Sakuraba; T Onuki; S Nitta
Journal:  Jpn J Thorac Cardiovasc Surg       Date:  2001-12

Review 2.  Therapies Directed Against B-Cells and Downstream Effectors in Generalized Autoimmune Myasthenia Gravis: Current Status.

Authors:  Grayson Beecher; Brendan Nicholas Putko; Amanda Nicole Wagner; Zaeem Azfer Siddiqi
Journal:  Drugs       Date:  2019-03       Impact factor: 9.546

Review 3.  B cells in the pathophysiology of myasthenia gravis.

Authors:  John S Yi; Jeffrey T Guptill; Panos Stathopoulos; Richard J Nowak; Kevin C O'Connor
Journal:  Muscle Nerve       Date:  2017-09-30       Impact factor: 3.217

4.  Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis.

Authors:  Panos Stathopoulos; Aditya Kumar; Richard J Nowak; Kevin C O'Connor
Journal:  JCI Insight       Date:  2017-09-07

5.  Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis.

Authors:  Ruoyi Jiang; Kenneth B Hoehn; Casey S Lee; Minh C Pham; Robert J Homer; Frank C Detterbeck; Inmaculada Aban; Leslie Jacobson; Angela Vincent; Richard J Nowak; Henry J Kaminski; Steven H Kleinstein; Kevin C O'Connor
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-16       Impact factor: 11.205

6.  Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature.

Authors:  Bettina Schreiner; Burkhard Becher; Florian Ingelfinger; Sinduya Krishnarajah; Michael Kramer; Sebastian G Utz; Edoardo Galli; Mirjam Lutz; Pascale Zwicky; Ayse U Akarca; Nicole Puertas Jurado; Can Ulutekin; David Bamert; Corinne C Widmer; Luca Piccoli; Federica Sallusto; Nicolás G Núñez; Teresa Marafioti; Didier Schneiter; Isabelle Opitz; Antonio Lanzavecchia; Hans H Jung; Donatella De Feo; Sarah Mundt
Journal:  Acta Neuropathol       Date:  2021-03-28       Impact factor: 17.088

7.  Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma.

Authors:  Yoshiaki Yasumizu; Naganari Ohkura; Hisashi Murata; Makoto Kinoshita; Soichiro Funaki; Satoshi Nojima; Kansuke Kido; Masaharu Kohara; Daisuke Motooka; Daisuke Okuzaki; Shuji Suganami; Eriko Takeuchi; Yamami Nakamura; Yusuke Takeshima; Masaya Arai; Satoru Tada; Meinoshin Okumura; Eiichi Morii; Yasushi Shintani; Shimon Sakaguchi; Tatsusada Okuno; Hideki Mochizuki
Journal:  Nat Commun       Date:  2022-07-22       Impact factor: 17.694

Review 8.  Short- and Long-Lived Autoantibody-Secreting Cells in Autoimmune Neurological Disorders.

Authors:  C Zografou; A G Vakrakou; P Stathopoulos
Journal:  Front Immunol       Date:  2021-06-17       Impact factor: 7.561

Review 9.  Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology.

Authors:  Miriam L Fichtner; Ruoyi Jiang; Aoibh Bourke; Richard J Nowak; Kevin C O'Connor
Journal:  Front Immunol       Date:  2020-05-27       Impact factor: 7.561
  9 in total

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