Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inhibition of acyl CoA: cholesterol acyltransferase and sterologenesis in rat liver by diazepam, in vitro.

Literature DB >> 3982236

Inhibition of acyl CoA: cholesterol acyltransferase and sterologenesis in rat liver by diazepam, in vitro.

Abstract

Diazepam, a commonly prescribed tranquilizer, was found to inhibit cholesterol biosynthesis in rat liver minces; inhibition appeared to occur at multiple post-mevalonate sites. Diazepam also inhibited cholesterol esterification by acylCoA:cholesterol acyltransferase in isolated liver microsomes and minces. Liver minces incubated with [14C]oleate demonstrated increased uptake of the fatty acid and a greater incorporation of the substrate into triglycerides, diglycerides and phospholipids when diazepam was present. The results suggest possible mechanisms for the hypocholesterolemic effect of diazepam in experimental animals and for the elevation of triglycerides and very low-density lipoproteins in man and the rat.

Entities: Chemical Species

Mesh：

Substances：

Year: 1985 PMID： 3982236 DOI： 10.1007/bf02534211

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

31 in total

1. The influence of cholesterol on the activity, on the isothermic kinetics and on the temperature-induced kinetics of 3-hydroxy-3-methylglutaryl coenzyme a reductase.

Authors: K A Mitropoulos; S Venkatesan
Journal: Biochim Biophys Acta Date: 1977-10-24

2. Influence of some psychotropic drugs on the development of experimental atherosclerosis.

Authors: B Cuparencu; I Ticşa; L Safta; A Rosenberg; R Mocan; G Brief
Journal: Cor Vasa Date: 1969

3. Effect of phthalate esters on serum cholesterol and lipid biosynthesis in liver, testes, and epididymal fat in the rat and rabbit.

Authors: F P Bell; C S Patt; P J Gillies
Journal: Lipids Date: 1978-10 Impact factor: 1.880

4. Biosynthesis of various sterols, sterol esters, and squalene from [14C]mevalonate by normal swine intima and media in vitro: a comparative study.

Authors: F P Bell
Journal: Exp Mol Pathol Date: 1976-12 Impact factor: 3.362

5. Evidence for boundary lipid in membranes.

Authors: P C Jost; O H Griffith; R A Capaldi; G Vanderkooi
Journal: Proc Natl Acad Sci U S A Date: 1973-02 Impact factor: 11.205

6. The effect of bilayer thickness on the activity of (Na+ + K+)-ATPase.

Authors: A Johannsson; G A Smith; J C Metcalfe
Journal: Biochim Biophys Acta Date: 1981-03-06

7. Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA:cholesterol acyltransferase and normal pancreatic function.

Authors: S B Clark; A M Tercyak
Journal: J Lipid Res Date: 1984-02 Impact factor: 5.922

1. The immunosuppressive substance 2-chloro-2-deoxyadenosine modulates lipoprotein metabolism in a murine macrophage cell line (P388 cells).

Authors: M Lechleitner; B Auer; U Zilian; F Hoppichler; M Schirmer; B Föger; F Geisen; J R Patsch; G Konwalinka
Journal: Lipids Date: 1994-09 Impact factor: 1.880

1 in total