Literature DB >> 3981953

Effects of nicotine and its major metabolites on blood pressure in anaesthetized rats.

P Dominiak, G Fuchs, S von Toth, H Grobecker.   

Abstract

Blood pressure and heart rate in anaesthetized rats has been determined after i.v. injection of increasing doses of nicotine (NI) and its major metabolites, i.e. continine (CO), nornicotine (NOR), metanicotine (MN) and dihydrometanicotine (DMN). NI and MN elicited similar dose response curves, increasing blood pressure according to the dose injected. However, the dose response curve of MN was shifted to the right. Furthermore DMN caused similar pressor effects than MN and the pressor effects of NOR was even weaker. Only after injection of CO was a dose-dependent depressor effect observed and this was reversed after very high doses. CO also reduced heart rate in a dose-dependent manner, whereas NI and its other metabolites did not significantly change heart rate.

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Year:  1985        PMID： 3981953     DOI： 10.1007/bf01733074

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN： 0023-2173


  8 in total

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Journal:  Klin Wochenschr       Date:  1984

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8.  Changes in peripheral and central catecholaminergic and serotoninergic neurons of rats after acute and subacute administration of nicotine.

Authors:  P Dominiak; F Kees; H Grobecker
Journal:  Klin Wochenschr       Date:  1984
  8 in total
  10 in total

1.  A microdialysis study of the effects of the nicotinic agonist RJR-2403 on cortical release of acetylcholine and biogenic amines.

Authors:  K L Summers; P Lippiello; E Giacobini
Journal:  Neurochem Res       Date:  1996-10       Impact factor: 3.996

2.  Effects of nornicotine enantiomers on intravenous S(-)-nicotine self-administration and cardiovascular function in rats.

Authors:  D J Stairs; N M Neugebauer; X Wei; C Boustany; M Hojahmat; L A Cassis; P A Crooks; L P Dwoskin; M T Bardo
Journal:  Psychopharmacology (Berl)       Date:  2006-11-10       Impact factor: 4.530

3.  Time-course of extracellular nicotine and cotinine levels in rat brain following administration of nicotine: effects of route and ethanol coadministration.

Authors:  Simon N Katner; Jamie E Toalston; Michael P Smoker; Zachary A Rodd; William J McBride; Eric A Engleman
Journal:  Psychopharmacology (Berl)       Date:  2014-07-20       Impact factor: 4.530

4.  A physiologically based pharmacokinetic model for nicotine and cotinine in man.

Authors:  D E Robinson; N J Balter; S L Schwartz
Journal:  J Pharmacokinet Biopharm       Date:  1992-12

5.  Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic receptors in monkey striatum.

Authors:  Kathryn O'Leary; Neeraja Parameswaran; J Michael McIntosh; Maryka Quik
Journal:  J Pharmacol Exp Ther       Date:  2008-02-27       Impact factor: 4.030

6.  Constant-rate infusion of nicotine and cotinine. I. A physiological pharmacokinetic analysis of the cotinine disposition, and effects on clearance and distribution in the rat.

Authors:  J Gabrielsson; U Bondesson
Journal:  J Pharmacokinet Biopharm       Date:  1987-12

Review 7.  New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine.

Authors:  J Alex Grizzell; Valentina Echeverria
Journal:  Neurochem Res       Date:  2014-06-27       Impact factor: 3.996

Review 8.  Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions.

Authors:  Xiaoying Tan; Kent Vrana; Zheng-Ming Ding
Journal:  Front Behav Neurosci       Date:  2021-10-21       Impact factor: 3.617

9.  Roles of alpha-7 nicotinic acetylcholine receptors and spleen in the lung injury induced by a repeated saline lavage in rat.

Authors:  Hossein Fatemikia; Amirreza Dehghanian; Bizhan Ziaian; Maryam Farokhipour; Farzaneh Ketabchi
Journal:  BMC Pulm Med       Date:  2022-09-27       Impact factor: 3.320

10.  Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure.

Authors:  Joohee Park; Antoine Taly; Jennifer Bourreau; Frédéric De Nardi; Claire Legendre; Daniel Henrion; Nathalie C Guérineau; Christian Legros; César Mattei; Hélène Tricoire-Leignel
Journal:  Int J Mol Sci       Date:  2021-05-12       Impact factor: 5.923
  10 in total

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