Literature DB >> 3980655

Rapid gas chromatographic--mass spectrometric quantitation of gamma-aminobutyric acid in biological specimens.

E J Norman, E L Wee, H K Berry, E F Zimmerman.   

Abstract

A mass fragmentographic method for gamma-aminobutyric acid (GABA) quantitation using the heptafluorobutyryl-cyclohexyl-GABA derivative is described. Both capillary and packed column gas chromatography were used. This procedure employs 2,2[2H2]GABA as an internal standard and allows the rapid, sensitive, and specific measurement of GABA with a minimum of sample clean-up. Application of the method is demonstrated in mouse embryonic brain, body, and palate and human platelets, plasma, cerebrospinal fluid, and urine.

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Year:  1985        PMID: 3980655

Source DB:  PubMed          Journal:  J Chromatogr


  2 in total

Review 1.  Clinical relevance of measuring GABA concentrations in cerebrospinal fluid.

Authors:  P J Schechter; A Sjoerdsma
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

2.  GABA uptake in embryonic palate mesenchymal cells of two mouse strains.

Authors:  E L Wee; E F Zimmerman
Journal:  Neurochem Res       Date:  1985-12       Impact factor: 3.996

  2 in total

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