Literature DB >> 3978312

Characterization of the receptor mediating contraction of human umbilical artery by 5-hydroxytryptamine.

J C McGrath, S J MacLennan, K Stuart-Smith.   

Abstract

The 5-hydroxytryptamine (5-HT) receptor in human umbilical artery was found to be similar to that in rabbit aorta. The pD2 was 7.45, pA2 for methysergide 8.63 and pA2 for phentolamine 6.21. Noradrenaline gave only very weak contractions at non-physiological concentrations. Amidephrine and xylazine did not contract human umbilical artery. It is concluded that there is no significant population of functional alpha-adrenoceptors in this vessel. The implications of these findings are discussed in relation to the control of the umbilical circulation.

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Year:  1985        PMID： 3978312      PMCID： PMC1987225          DOI： 10.1111/j.1476-5381.1985.tb17370.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  4 in total

1.  Effects of vasoactive agents on isolated human umbilical arteries and veins.

Authors:  B M Altura; D Malaviya; C F Reich; L R Orkin
Journal:  Am J Physiol       Date:  1972-02

2.  d-Lysergic acid diethylamide (LSD-25): a constrictor of human umbilical vein.

Authors:  D W Gant; D C Dyer
Journal:  Life Sci I       Date:  1971-02-15

3.  Ketanserin--a novel antihypertensive drug?

Authors:  P P Humphrey; W Feniuk; A D Watts
Journal:  J Pharm Pharmacol       Date:  1982-08       Impact factor: 3.765

4.  Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta.

Authors:  E Apperley; P P Humphrey; G P Levy
Journal:  Br J Pharmacol       Date:  1976-10       Impact factor: 8.739
  4 in total
  2 in total

1.  5-HT1-like receptors requiring functional cyclo-oxygenase and 5-HT2 receptors independent of cyclo-oxygenase mediate contraction of the human umbilical artery.

Authors:  S J MacLennan; M J Whittle; J C McGrath
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

2.  Contraction of human umbilical artery, but not vein, by oxygen.

Authors:  J C McGrath; S J MacLennan; A C Mann; K Stuart-Smith; M J Whittle
Journal:  J Physiol       Date:  1986-11       Impact factor: 5.182
  2 in total

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