Literature DB >> 3977904

Endogenous free radical generation may influence proteolysis in mitochondria.

R T Dean, J K Pollak.   

Abstract

Isolated Mitochondria were allowed to incorporate radioactive amino acids into protein and proteolysis was then measured. In State 4 free radical generation was manipulated by means of respiratory chain blockers and uncouplers. Conditions of enhanced radical flux resulted in accelerated protein breakdown. We suggest that radicals influence proteolysis in cells both directly (by fragmenting proteins) and indirectly (by rendering proteins more susceptible to proteinases).

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3977904     DOI： 10.1016/0006-291x(85)90296-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Inhibition of monoamine oxidase activity by repetitive transcranial magnetic stimulation: implications for inter-train interval and frequency.

Authors:  Michael Kaczmarczyk; Francesca Regen; Isabella Heuser; Malek Bajbouj; Julian Hellmann-Regen
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2018-12-17       Impact factor: 5.270

2.  Studies on the mechanism of photosystem II photoinhibition II. The involvement of toxic oxygen species.

Authors:  M Richter; W Rühle; A Wild
Journal:  Photosynth Res       Date:  1990-06       Impact factor: 3.573

3.  Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins.

Authors:  O Marcillat; Y Zhang; S W Lin; K J Davies
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

4.  Hydroperoxide-mediated fragmentation of proteins.

Authors:  J V Hunt; J A Simpson; R T Dean
Journal:  Biochem J       Date:  1988-02-15       Impact factor: 3.857

Review 5.  Biochemistry and pathology of radical-mediated protein oxidation.

Authors:  R T Dean; S Fu; R Stocker; M J Davies
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

6.  Influence of some biological response modifiers on swelling of rat liver mitochondria in vitro.

Authors:  S Mehrotra; P N Viswanathan; P Kakkar
Journal:  Mol Cell Biochem       Date:  1993-07-21       Impact factor: 3.396

7.  Free-radical-mediated fragmentation of monoamine oxidase in the mitochondrial membrane. Roles for lipid radicals.

Authors:  R T Dean; S M Thomas; A Garner
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857

8.  Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis.

Authors:  S P Wolff; R T Dean
Journal:  Biochem J       Date:  1986-03-01       Impact factor: 3.857

9.  Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Authors:  D Vercammen; R Beyaert; G Denecker; V Goossens; G Van Loo; W Declercq; J Grooten; W Fiers; P Vandenabeele
Journal:  J Exp Med       Date:  1998-05-04       Impact factor: 14.307

Review 10.  The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders.

Authors:  Anuradha Tarafdar; Giordano Pula
Journal:  Int J Mol Sci       Date:  2018-11-30       Impact factor: 5.923
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.