Literature DB >> 3977834

Leucine and tryptophan metabolism in rats.

M Salter, D A Bender, C I Pogson.   

Abstract

The rate of tryptophan metabolism in isolated liver cells from animals fed on a high-leucine diet was greater than for cells from control animals. Leucine inhibited tryptophan metabolism and tryptophan uptake in isolated liver cells, probably by competing for membrane transport. Leucine had no effect on tryptophan 2,3-dioxygenase in vitro. 4-Methyl-2-oxovalerate increased tryptophan oxidation in incubations containing albumin, by displacing bound tryptophan and increasing the availability of the amino acid to the cell. The results suggest that, under extreme conditions, when the availability of tryptophan is low, leucine may be pellagragenic.

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Year:  1985        PMID： 3977834      PMCID： PMC1144587          DOI： 10.1042/bj2250277

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  27 in total

1.  Leucine and pellagra.

Authors:  C GOPALAN; S G SRIKANTIA
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2.  Effect of leucine on enzymes of the tryptophan-niacin metabolic pathway in rat liver and kidney.

Authors:  B S Rao
Journal:  Biochem J       Date:  1973-06       Impact factor: 3.857

3.  NAD glycohydrolase activity in the liver of rats fed on excess leucine diet and low or high protein diet.

Authors:  H Kubota; K Nomura; O Yamada; M Shin; K Sano; C Umezawa
Journal:  J Nutr Sci Vitaminol (Tokyo)       Date:  1982-02       Impact factor: 2.000

4.  Evidence for two Na+-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. Time-dependent changes in activity.

Authors:  L Weissbach; M E Handlogten; H N Christensen; M S Kilberg
Journal:  J Biol Chem       Date:  1982-10-25       Impact factor: 5.157

5.  Effects of excess intake of leucine and valine deficiency on tryptophan and niacin metabolites in humans.

Authors:  I Nakagawa; S Oguri; A Sasaki; M Kajimoto; M Sasaki
Journal:  J Nutr       Date:  1975-10       Impact factor: 4.798

6.  The effect of a high level of dietary leucine on the niacin status of chicks and rats.

Authors:  J A Manson; K J Carpenter
Journal:  J Nutr       Date:  1978-12       Impact factor: 4.798

7.  Binding of branched-chain 2-oxo acids to bovine serum albumin.

Authors:  G Livesey; P Lund
Journal:  Biochem J       Date:  1982-04-15       Impact factor: 3.857

8.  Effects of a dietary excess of leucine on the metabolism of tryptophan in the rat: a mechanism for the pellagragenic action of leucine.

Authors:  D A Bender
Journal:  Br J Nutr       Date:  1983-07       Impact factor: 3.718

9.  Effect of dietary excess leucine on the levels of branched chain alpha-keto acids and ketone bodies in blood and the liver of rats.

Authors:  O Yamada; M Shin; K Sano; C Umezawa
Journal:  Int J Vitam Nutr Res       Date:  1983       Impact factor: 1.784

10.  Distribution of branched-chain alpha-keto acid dehydrogenases in primate tissues.

Authors:  B S Khatra; R K Chawla; C W Sewell; D Rudman
Journal:  J Clin Invest       Date:  1977-03       Impact factor: 14.808
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6.  Mechanisms of the pellagragenic effect of leucine: stimulation of hepatic tryptophan oxidation by administration of branched-chain amino acids to healthy human volunteers and the role of plasma free tryptophan and total kynurenines.

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8.  Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion.

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