Literature DB >> 397765

Thromboxane A2 biosynthesis during endotoxin-induced aggregation of platelets from normal and sensitized guinea-pigs.

H Bult, A G Herman.   

Abstract

Endotoxin lipopolysaccharides Escherichia coli O26:B6 and E. coli O127:B8 were weak inducers of aggregation in normal guinea-pig platelet-rich plasma (PRP), even in the presence of Ca2+. Indomethacin hardly inhibited endotoxin-induced aggregation, indicating that biosynthesis of thromboxane A2 (TXA2) was of little importance. In accordance with this conclusion TXA2 was not detectable by means of bioassay during endotoxin-induced aggregation in normal guinea-pig PRP. Pretreatment of the guinea-pigs with endotoxin sensitized their PRP to endotoxin. This was due to a humoral factor with a selectively directed towards the polysaccharide moiety of endotoxin. The combination of this factor with endotoxin indued a marked biosynthesis of TXA2 and concomitant platelet aggregation.

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Year:  1979        PMID： 397765     DOI： 10.1007/bf01968128

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  11 in total

1.  Bioassay by cascade superfusion using a highly sensitive laminar flow technique.

Authors:  H Bult; M J Parnham; I L Bonta
Journal:  J Pharm Pharmacol       Date:  1977-06       Impact factor: 3.765

2.  THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD.

Authors:  J R VANE
Journal:  Br J Pharmacol Chemother       Date:  1964-10

3.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

4.  Platelet aggregation in rabbits made tolerant to endotoxin.

Authors:  R I Walker; L J Shields; J R Fletcher
Journal:  Infect Immun       Date:  1978-03       Impact factor: 3.441

5.  Influence of different drugs on the slow response of the intestine during the Schultz-Dale reaction.

Authors:  G M Laekeman; A G Herman; J M van Nueten
Journal:  Arch Int Pharmacodyn Ther       Date:  1977-12

6.  Endotoxin-induced platelet aggregation and secretion. I. Morphological changes and pharmacological effects.

Authors:  D E MacIntyre; A P Allen; K J Thorne; A M Glauert; J L Gordon
Journal:  J Cell Sci       Date:  1977-12       Impact factor: 5.285

7.  Interactions of the classical and alternate complement pathway with endotoxin lipopolysaccharide. Effect on platelets and blood coagulation.

Authors:  M A Kane; J E May; M M Frank
Journal:  J Clin Invest       Date:  1973-02       Impact factor: 14.808

8.  Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.

Authors:  C Malmsten; M Hamberg; J Svensson; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

9.  Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Authors:  M Hamberg; J Svensson; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

10.  Effects of bacterial endotoxin on rabbit platelets. IV. The divalent ion requirements of endotoxin-induced and immunologically induced platelet injury.

Authors:  R M Des Prez; R E Bryant
Journal:  J Exp Med       Date:  1966-11-01       Impact factor: 14.307
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  3 in total

Review 1.  Interaction of platelets with bacterial endotoxins.

Authors:  N Semeraro; A Lattanzio
Journal:  Agents Actions       Date:  1983-08

2.  Activated complement and anaphylatoxins increase the in vitro production of prostacyclin by rabbit aorta endothelium.

Authors:  M Rampart; H Bult; A G Herman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000

3.  Endotoxin inhalation induces neutrophil chemotaxis by alveolar macrophages.

Authors:  M C Snella; R Rylander
Journal:  Agents Actions       Date:  1985-09
  3 in total

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