Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A rabbit model of intracerebral hematoma.

Literature DB >> 3976368

A rabbit model of intracerebral hematoma.

H H Kaufman, J L Pruessner, D P Bernstein, A Borit, P T Ostrow, D L Cahall.

Abstract

The epiphenomena that seem to cause deterioration and death after spontaneous interacerebral hematoma (SICH) might best be studied in an animal model. Therefore, the principles for developing such a model and techniques to study these phenomena were evaluated. Animals will tolerate injection of 3%-5% of their brain volume with a high proportion of clots. Fluorescein can be used to study the blood-brain barrier, and gravimetry to study edema. Others have found that injection of a paraffin/oil mixture can be employed for a control model. Refinement of the fluorescein technique, development of a primate model, and directions for future research are suggested.

Entities: Chemical Disease Species

Mesh：

Substances：
Fluoresceins
Fluorescein

Year: 1985 PMID： 3976368 DOI： 10.1007/bf00687015

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

15 in total

1. The rabbit diencephalon in stereotaxic coordinates.

Authors: C H SAWYER; J W EVERETT; J D GREEN
Journal: J Comp Neurol Date: 1954-12 Impact factor: 3.215

2. Hypertensive intracerebral hematoma. An investigation of the initial hemorrhage and rebleeding using chromium Cr 51-labeled erythrocytes.

Authors: D J Herbstein; H H Schaumberg
Journal: Arch Neurol Date: 1974-05

A rabbit model of intracerebral hematoma.

1. The rabbit diencephalon in stereotaxic coordinates.

2. Hypertensive intracerebral hematoma. An investigation of the initial hemorrhage and rebleeding using chromium Cr 51-labeled erythrocytes.

3. Fatal hypertensive intracerebral haematomas: a survey of the pathological anatomy of 393 cases.

4. A model of focal cortical contusion in gerbils.

5. Measurement of the specific gravity of the brain as a tool in brain edema research.

6. A simple gravimetric technique for measurement of cerebral edema.

7. The determination of brain water content: microgravimetry versus drying-weighing method.

8. An improved gravimetric measure of cerebral edema.

9. Natural history of experimental intracerebral hemorrhage: sonography, computed tomography and neuropathology.

10. Evaluation of the dye-protein tracers in pathophysiology of the blood-brain barrier.

Review 1. History of preclinical models of intracerebral hemorrhage.

Review 2. Experimental intracerebral hemorrhage: avoiding pitfalls in translational research.

Review 3. Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke.

4. Amount of bleeding and hematoma size in the collagenase-induced intracerebral hemorrhage rat model.

5. The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage.

Review 6. Progress in translational research on intracerebral hemorrhage: is there an end in sight?

Review 7. Preclinical models of intracerebral hemorrhage: a translational perspective.

8. Insights into the development and treatment of cardiovascular disease: a role for animal models.