Literature DB >> 3975627

Blood-brain barrier: endogenous modulation by adrenal-cortical function.

J B Long, J W Holaday.   

Abstract

The blood-brain barrier restricts the passage of molecules from the blood to the brain. The permeability of the barrier to iodine-125-labeled bovine serum albumin was examined in rats that had undergone adrenalectomy, adrenal demedullation, and corticosterone replacement. Adrenalectomy, but not adrenal demedullation, increased the permeability of brain tissue to the isotopically labeled macromolecule; corticosterone replacement reversed this effect. These results indicate that the blood-brain barrier may be hormonally regulated; that is, the pituitary-adrenal axis may physiologically modulate the permeability of the brain microvasculature to macromolecules.

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Year:  1985        PMID： 3975627     DOI： 10.1126/science.3975627

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

Review 1.  Fifteenth Gaddum Memorial Lecture December 1994. Stress and the neuroendocrine-immune axis: the pivotal role of glucocorticoids and lipocortin 1.

Authors:  J C Buckingham
Journal:  Br J Pharmacol       Date:  1996-05       Impact factor: 8.739

2.  The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system.

Authors:  J B van Bree; A V Baljet; A van Geyt; A G de Boer; M Danhof; D D Breimer
Journal:  J Pharmacokinet Biopharm       Date:  1989-08

3.  Hypoxia-induced increases in pulmonary transvascular protein escape in rats. Modulation by glucocorticoids.

Authors:  T J Stelzner; R F O'Brien; K Sato; J V Weil
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

4.  The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin.

Authors:  Anargyros Xenocostas; Wing K Cheung; Francis Farrell; Cindy Zakszewski; Marian Kelley; Andrzej Lutynski; Michael Crump; Jeffrey H Lipton; Thomas L Kiss; Catherine Y Lau; Hans A Messner
Journal:  Eur J Clin Pharmacol       Date:  2005-03-18       Impact factor: 2.953

5.  Intravenous injection of horseradish peroxidase in the rat stimulates corticosterone and adrenocorticotropic hormone release.

Authors:  D Jezová; Y Olsson
Journal:  Acta Neuropathol       Date:  1986       Impact factor: 17.088

6.  Haemophilus influenzae lipopolysaccharide-induced blood brain barrier permeability during experimental meningitis in the rat.

Authors:  B Wispelwey; A J Lesse; E J Hansen; W M Scheld
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

7.  Ontogeny and the effects of exogenous and endogenous glucocorticoids on tight junction protein expression in ovine cerebral cortices.

Authors:  Anna R Duncan; Grazyna B Sadowska; Barbara S Stonestreet
Journal:  Brain Res       Date:  2009-09-26       Impact factor: 3.252

8.  Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology.

Authors:  K S Tung; S Smith; C Teuscher; C Cook; R E Anderson
Journal:  Am J Pathol       Date:  1987-02       Impact factor: 4.307

9.  Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.

Authors:  V J Quagliarello; W J Long; W M Scheld
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

10.  The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics.

Authors:  E C de Lange; M B Hesselink; M Danhof; A G de Boer; D D Breimer
Journal:  Pharm Res       Date:  1995-01       Impact factor: 4.200
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