| Literature DB >> 3975623 |
Y Yonekura, A B Brill, P Som, K Yamamoto, S C Srivastava, J Iwai, D R Elmaleh, E Livni, H W Strauss, M M Goodman.
Abstract
Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.Entities:
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Year: 1985 PMID： 3975623 DOI： 10.1126/science.3975623
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728