Literature DB >> 3974605

DNA-damaging properties and cytotoxicity in human fibroblasts of tetrachlorohydroquinone, a pentachlorophenol metabolite.

I Witte, U Juhl, W Butte.   

Abstract

The DNA-damaging potential of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCH) was investigated. TCH was found to bind covalently to calf-thymus DNA and to cause single-strand breaks in PM2 DNA. No DNA-damaging effects were observed for PCP. Exposure of human fibroblasts to PCP and TCH showed that TCH is more toxic, when colony-forming ability after exposure to the agent is used as a measure of toxicity. In the evaluation of the mutagenic and carcinogenic potential of PCP the metabolite TCH should be taken into consideration.

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Year:  1985        PMID： 3974605     DOI： 10.1016/0167-8817(85)90042-2

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  7 in total

1.  In vivo levels of chlorinated hydroquinones in a pentachlorophenol-degrading bacterium.

Authors:  D L McCarthy; A A Claude; S D Copley
Journal:  Appl Environ Microbiol       Date:  1997-05       Impact factor: 4.792

2.  Estimation of selected phenols in drinking water with in situ acetylation and study on the DNA damaging properties of polychlorinated phenols.

Authors:  Y J Wang; J K Lin
Journal:  Arch Environ Contam Toxicol       Date:  1995-05       Impact factor: 2.804

3.  Metabolism of pentachlorophenol to tetrachlorohydroquinone by human liver homogenate.

Authors:  U Juhl; I Witte; W Butte
Journal:  Bull Environ Contam Toxicol       Date:  1985-11       Impact factor: 2.151

4.  Oral administration of pentachlorophenol impairs antioxidant system, inhibits enzymes of brush border membrane, causes DNA damage and histological changes in rat intestine.

Authors:  Nikhil Maheshwari; Aijaz Ahmed Khan; Asif Ali; Riaz Mahmood
Journal:  Toxicol Res (Camb)       Date:  2022-06-28       Impact factor: 2.680

5.  Disposition, bioavailability, and serum protein binding of pentachlorophenol in the B6C3F1 mouse.

Authors:  B G Reigner; J F Rigod; T N Tozer
Journal:  Pharm Res       Date:  1992-08       Impact factor: 4.200

6.  Effects of pentachlorophenol and tetrachlorohydroquinone on mitogen-activated protein kinase pathways in Jurkat T cells.

Authors:  Bambang Wispriyono; Masato Matsuoka; Hideki Igisu
Journal:  Environ Health Perspect       Date:  2002-02       Impact factor: 9.031

7.  Residues His172 and Lys238 are Essential for the Catalytic Activity of the Maleylacetate Reductase from Sphingobium chlorophenolicum Strain L-1.

Authors:  Lifeng Chen; Ed S Krol; Meena K Sakharkar; Haseeb A Khan; Abdullah S Alhomida; Jian Yang
Journal:  Sci Rep       Date:  2017-12-22       Impact factor: 4.379
  7 in total

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