Literature DB >> 3974228

Aromatization of androstenedione by normal and neoplastic endometrium of the uterus.

J Yamaki, T Yamamoto, H Okada.   

Abstract

The ability of human uterine endometrium to aromatize androstenedione to estrogens was investigated using 10 normal and neoplastic tissues. Normal and neoplastic endometrial homogenates were incubated with [6,7-3H]androstenedione (A) and NADPH. Estrone (E1) and estradiol (E2) were subsequently isolated in amounts ranging from 0-17600 fmol/h/g and 0-377 fmol/h/g, respectively, from the incubates after purifications by using Bio-Rad AG1-X2 column, thin layer chromatographies and co-crystallization. The conversion of A to E1 and E2 was significantly higher in neoplastic tissues.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3974228     DOI： 10.1016/0022-4731(85)90142-6

Source DB:  PubMed          Journal:  J Steroid Biochem        ISSN： 0022-4731            Impact factor:   4.292


  10 in total

1.  The inductive effects of progestogens on aromatase activity in stromal cells of human uterine endometrium.

Authors:  T Yamamoto; K Shiroshita; J Kitawaki; H Okada
Journal:  J Endocrinol Invest       Date:  1989-03       Impact factor: 4.256

2.  Organoruthenium(II) Complexes Bearing an Aromatase Inhibitor: Synthesis, Characterization, in Vitro Biological Activity and in Vivo Toxicity in Zebrafish Embryos.

Authors:  Golara Golbaghi; Mohammad Mehdi Haghdoost; Debbie Yancu; Yossef López de Los Santos; Nicolas Doucet; Shunmoogum A Patten; J Thomas Sanderson; Annie Castonguay
Journal:  Organometallics       Date:  2019-01-31       Impact factor: 3.876

3.  Immunohistochemical analysis of 17β-hydroxysteroid dehydrogenase isozymes in human ovarian surface epithelium and epithelial ovarian carcinoma.

Authors:  Ken-ichi Motohara; Hironori Tashiro; Yumiko Taura; Takashi Ohba; Hidetaka Katabuchi
Journal:  Med Mol Morphol       Date:  2011-01-26       Impact factor: 2.309

Review 4.  Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery.

Authors:  Gonda Konings; Linda Brentjens; Bert Delvoux; Tero Linnanen; Karlijn Cornel; Pasi Koskimies; Marlies Bongers; Roy Kruitwagen; Sofia Xanthoulea; Andrea Romano
Journal:  Front Pharmacol       Date:  2018-09-19       Impact factor: 5.810

5.  Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies.

Authors:  K Watanabe; H Sasano; N Harada; M Ozaki; H Niikura; S Sato; A Yajima
Journal:  Am J Pathol       Date:  1995-02       Impact factor: 4.307

6.  From Endocrinology to Intracrinology.

Authors:  Hironobu Sasano; Takashi Suzuki; Nobuhiro Harada
Journal:  Endocr Pathol       Date:  1998       Impact factor: 3.943

7.  Inflammatory status influences aromatase and steroid receptor expression in endometriosis.

Authors:  Orhan Bukulmez; Daniel B Hardy; Bruce R Carr; R Ann Word; Carole R Mendelson
Journal:  Endocrinology       Date:  2007-11-29       Impact factor: 4.736

8.  Investigation of aromatase inhibitory activity of metal complexes of 8-hydroxyquinoline and uracil derivatives.

Authors:  Veda Prachayasittikul; Ratchanok Pingaew; Chanin Nantasenamat; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul
Journal:  Drug Des Devel Ther       Date:  2014-08-14       Impact factor: 4.162

9.  Tissue-specific regulation of pregnane X receptor in cancer development and therapy.

Authors:  Delira Robbins; Taosheng Chen
Journal:  Cell Biosci       Date:  2014-04-01       Impact factor: 7.133

10.  Prediction of aromatase inhibitory activity using the efficient linear method (ELM).

Authors:  Watshara Shoombuatong; Veda Prachayasittikul; Virapong Prachayasittikul; Chanin Nantasenamat
Journal:  EXCLI J       Date:  2015-03-20       Impact factor: 4.068
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.