Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Protective role of faecal pH in experimental colon carcinogenesis.

Literature DB >> 3973888

Protective role of faecal pH in experimental colon carcinogenesis.

Abstract

There is epidemiological evidence that populations with alkaline stool pH are at greater risk for colon cancer than populations with acid stool pH. This association was investigated in the laboratory using the rat-dimethylhydrazine colon carcinogenesis model. Rats with acid stool pH, produced by consumption of lactulose or sodium sulphate or both, had significantly fewer colon tumours after injections of dimethylhydrazine (DMH) than rats treated with DMH alone. The results confirm the hypothesis that acidification of the stool can protect against the induction of colon cancer.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1985 PMID： 3973888 PMCID： PMC1289639 DOI： 10.1177/014107688507800311

Source DB: PubMed Journal: J R Soc Med ISSN： 0141-0768 Impact factor: 5.344

14 in total

1. The effect of wheat bran upon bile salt metabolism and upon the lipid composition of bile in gallstone patients.

Authors: E W Pomare; K W Heaton; T S Low-Beer; H J Espiner
Journal: Am J Dig Dis Date: 1976-07

2. Cellulose dietary bulk and azoxymethane-induced intestinal cancer.

Authors: J M Ward; R S Yamamoto; J H Weisburger
Journal: J Natl Cancer Inst Date: 1973-08 Impact factor: 13.506

3. Relationship of experimentally induced intestinal tumors to laxative ingestion.

Authors: J C Cleveland; J W Cole
Journal: Cancer Date: 1969-05 Impact factor: 6.860

4. Experimental colon cancer: what animal models have demonstrated about the origin of human colon cancer.

Authors: R L Nelson
Journal: Curr Surg Date: 1983 Nov-Dec

5. [Cholecystectomy and experimental coloncarcinoma (author's transl)].

Authors: B Werner; K de Heer; H Mitschke
Journal: Langenbecks Arch Chir Date: 1977-04-22

6. Cholecystectomy and carcinoma of the colon.

Authors: D Linos; C M Beard; W M O'Fallon; M B Dockerty; R W Beart; L T Kurland
Journal: Lancet Date: 1981-08-22 Impact factor: 79.321

7. Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device.

Authors: R L Bown; J A Gibson; G E Sladen; B Hicks; A M Dawson
Journal: Gut Date: 1974-12 Impact factor: 23.059

8. Fecal hydroxysteroid dehydrogenase activities in vegetarian Seventh-Day Adventists, control subjects, and bowel cancer patients.

Authors: I A Macdonald; G R Webb; D E Mahony
Journal: Am J Clin Nutr Date: 1978-10 Impact factor: 7.045

9. Prolonged survival and decrease in intestinal tumours in dimethylhydrazine-treated rats fed a chemically defined diet.

Authors: W M Castleden
Journal: Br J Cancer Date: 1977-04 Impact factor: 7.640

10. Faecal urobilinogen levels and pH of stools in population groups with different incidence of cancer of the colon, and their possible role in its aetiology.

Authors: S L Malhotra
Journal: J R Soc Med Date: 1982-09 Impact factor: 18.000

15 in total

Review 1. Most effective colon cancer chemopreventive agents in rats: a systematic review of aberrant crypt foci and tumor data, ranked by potency.

Authors: Denis E Corpet; Sylviane Taché
Journal: Nutr Cancer Date: 2002 Impact factor: 2.900

2. Limitations of faecal chymotrypsin as a screening test for chronic pancreatitis.

Authors: L Riedel; A R Walker; I Segal; A E Mohamed; A E Smyth; B Daya; I Naik
Journal: Gut Date: 1991-03 Impact factor: 23.059

3. Galacto-oligosaccharides and Colorectal Cancer: Feeding our Intestinal Probiome.

Authors: Jose M Bruno-Barcena; M Andrea Azcarate-Peril
Journal: J Funct Foods Date: 2015-01 Impact factor: 4.451

4. Effect of L-lactic acid, short-chain fatty acids, and pH in cecal infusate on morphometric and cell kinetic parameters of rat cecum.

Authors: H Ichikawa; T Sakata
Journal: Dig Dis Sci Date: 1997-08 Impact factor: 3.199

5. Screening of stimulatory effects of dietary risk factors on mouse intestinal cell kinetics.

Authors: Pooja Shivshankar; Shyamala-C-S Devi
Journal: World J Gastroenterol Date: 2005-01-14 Impact factor: 5.742

6. Effect of long term lactulose ingestion on secondary bile salt metabolism in man: potential protective effect of lactulose in colonic carcinogenesis.

Authors: G P van Berge Henegouwen; S D van der Werf; A T Ruben
Journal: Gut Date: 1987-06 Impact factor: 23.059

Review 7. Intervention studies in adenoma patients.

Authors: N C Armitage
Journal: World J Surg Date: 1991 Jan-Feb Impact factor: 3.352

8. New Plausible Mechanism for Gastric and Colorectal Carcinogenesis: Free Radical-Mediated Acetaldehyde Generation in a Heme/Myoglobin-Linoleate-Ethanol Mixture.

Authors: Hiroshi Kasai; Kazuaki Kawai
Journal: ACS Omega Date: 2021-04-28

9. The quest for targeted delivery in colon cancer: mucoadhesive valdecoxib microspheres.

Authors: Naveen K Thakral; Alok R Ray; Daniel Bar-Shalom; André Huss Eriksson; Dipak K Majumdar
Journal: Int J Nanomedicine Date: 2011-05-19

10. Free radical-mediated acetaldehyde formation by model reactions of dietary components: effects of meat, wine, cooking oil and coffee.

Authors: Hiroshi Kasai; Kazuaki Kawai
Journal: Genes Environ Date: 2021-07-09