Literature DB >> 3972125

Targeting of enzyme immobilized on erythrocyte membrane to collagen-coated surface.

V R Muzykantov, D V Sakharov, M D Smirnov, S P Domogatsky, G P Samokhin.   

Abstract

It is suggested to use 'enzyme(s)-erythrocyte-antibody' complex for modulation of the microenvironment in definite compartments of blood circulation. A model system including peroxidase, human erythrocytes and anti-collagen antibodies was chosen to illustrate the principle. Peroxidase was conjugated to the erythrocyte surface via periodate-oxidized enzyme carbohydrate moiety; biotinylated antibodies were linked by avidin to the biotinylated erythrocytes. The properties of the immunocomplexes obtained have been investigated in an artificial system simulating an injured blood vessel wall. The advantages in using erythrocyte-mediated immunoenzyme complexes for enzyme (drug) targeting are discussed.

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Year:  1985        PMID： 3972125     DOI： 10.1016/0014-5793(85)81154-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Targeting and depletion of circulating leukocytes and cancer cells by lipophilic antibody-modified erythrocytes.

Authors:  Rajesh Mukthavaram; Guixin Shi; Santosh Kesari; Dmitri Simberg
Journal:  J Control Release       Date:  2014-03-28       Impact factor: 9.776

Review 2.  Drug delivery by red blood cells: vascular carriers designed by mother nature.

Authors:  Vladimir R Muzykantov
Journal:  Expert Opin Drug Deliv       Date:  2010-04       Impact factor: 6.648

3.  Directed targeting of immunoerythrocytes provides local protection of endothelial cells from damage by hydrogen peroxide.

Authors:  V R Muzykantov; D V Sakharov; S P Domogatsky; N V Goncharov; S M Danilov
Journal:  Am J Pathol       Date:  1987-08       Impact factor: 4.307

Review 4.  Red blood cells: The metamorphosis of a neglected carrier into the natural mothership for artificial nanocarriers.

Authors:  Patrick M Glassman; Elizabeth D Hood; Laura T Ferguson; Zongmin Zhao; Don L Siegel; Samir Mitragotri; Jacob S Brenner; Vladimir R Muzykantov
Journal:  Adv Drug Deliv Rev       Date:  2021-09-29       Impact factor: 15.470

Review 5.  Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier.

Authors:  Carlos H Villa; Daniel C Pan; Sergei Zaitsev; Douglas B Cines; Donald L Siegel; Vladimir R Muzykantov
Journal:  Ther Deliv       Date:  2015-07

Review 6.  Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems.

Authors:  Carlos H Villa; Aaron C Anselmo; Samir Mitragotri; Vladimir Muzykantov
Journal:  Adv Drug Deliv Rev       Date:  2016-03-03       Impact factor: 15.470

7.  Avidin acylation prevents the complement-dependent lysis of avidin-carrying erythrocytes.

Authors:  V R Muzykantov; M D Smirnov; G P Samokhin
Journal:  Biochem J       Date:  1991-01-15       Impact factor: 3.857

8.  Delivering nanoparticles to lungs while avoiding liver and spleen through adsorption on red blood cells.

Authors:  Aaron C Anselmo; Vivek Gupta; Blaine J Zern; Daniel Pan; Michael Zakrewsky; Vladimir Muzykantov; Samir Mitragotri
Journal:  ACS Nano       Date:  2013-11-12       Impact factor: 15.881

9.  Red Blood Cell Hitchhiking: A Novel Approach for Vascular Delivery of Nanocarriers.

Authors:  Jacob S Brenner; Samir Mitragotri; Vladimir R Muzykantov
Journal:  Annu Rev Biomed Eng       Date:  2021-03-31       Impact factor: 11.324

Review 10.  Vascular Drug Delivery Using Carrier Red Blood Cells: Focus on RBC Surface Loading and Pharmacokinetics.

Authors:  Patrick M Glassman; Carlos H Villa; Anvay Ukidve; Zongmin Zhao; Paige Smith; Samir Mitragotri; Alan J Russell; Jacob S Brenner; Vladimir R Muzykantov
Journal:  Pharmaceutics       Date:  2020-05-09       Impact factor: 6.321
  10 in total

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