Literature DB >> 3972106

The aerobic/anaerobic transition of glucose metabolism in Trypanosoma brucei.

R Eisenthal, A Panes.   

Abstract

The ratio of glycerol to pyruvate produced by T. brucei incubated with glucose at various oxygen tensions has been used as an index of the aerobic and anaerobic pathways of glucose metabolism. A minimal model is presented which fits the observed data. The value of the notional K of the aerobic/anaerobic transition from the model is close to that of the Km of trypanosomal glycerophosphate oxidase. The anaerobic pathway appears to be almost completely inoperative at oxygen tensions in the range of those found in venous and arterial blood.

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Year:  1985        PMID： 3972106     DOI： 10.1016/0014-5793(85)81106-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes.

Authors:  Jurgen R Haanstra; Arjen van Tuijl; Peter Kessler; Willem Reijnders; Paul A M Michels; Hans V Westerhoff; Marilyn Parsons; Barbara M Bakker
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-13       Impact factor: 11.205

Review 2.  Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei.

Authors:  B M Bakker; H V Westerhoff; P A Michels
Journal:  J Bioenerg Biomembr       Date:  1995-10       Impact factor: 2.945

3.  Dihydrolipoamide dehydrogenase from Trypanosoma brucei. Characterization and cellular location.

Authors:  M J Danson; K Conroy; A McQuattie; K J Stevenson
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

4.  Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism.

Authors:  Fiona Achcar; Eduard J Kerkhoven; Barbara M Bakker; Michael P Barrett; Rainer Breitling
Journal:  PLoS Comput Biol       Date:  2012-01-19       Impact factor: 4.475

5.  Targeting pathogen metabolism without collateral damage to the host.

Authors:  Jurgen R Haanstra; Albert Gerding; Amalia M Dolga; Freek J. H. Sorgdrager; Manon Buist-Homan; François du Toit; Klaas Nico Faber; Hermann-Georg Holzhütter; Balázs Szöör; Keith R Matthews; Jacky L Snoep; Hans V Westerhoff; Barbara M Bakker
Journal:  Sci Rep       Date:  2017-01-13       Impact factor: 4.379

6.  Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditions.

Authors:  Erika Pineda; Magali Thonnus; Muriel Mazet; Arnaud Mourier; Edern Cahoreau; Hanna Kulyk; Jean-William Dupuy; Marc Biran; Cyril Masante; Stefan Allmann; Loïc Rivière; Brice Rotureau; Jean-Charles Portais; Frédéric Bringaud
Journal:  PLoS Pathog       Date:  2018-11-01       Impact factor: 6.823
  6 in total

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