Literature DB >> 3972093

Platelet insulin receptor determination in non-insulin dependent diabetes mellitus.

M Udvardy, G Pfliegler, K Rak.   

Abstract

The platelet membrane insulin receptors of healthy and non-insulin dependent (type 2) diabetic patients were studied. Receptor number and affinity proved to be decreased in type 2 diabetes mellitus. The changes in platelet insulin receptor characteristics are in good correlation with the alterations reported in other tissues or cells. The possible role of these phenomena in the pathogenesis of disturbed platelet function in diabetics needs further investigation.

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Year:  1985        PMID： 3972093     DOI： 10.1007/bf02004539

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  The monocyte as a model for the study of insulin receptors in man.

Authors:  H Beck-Nielsen; O Pedersen; K Kragballe; N S Sorensen
Journal:  Diabetologia       Date:  1977-12       Impact factor: 10.122

2.  Erythrocytes: a new cell type for the evaluation of insulin receptor defects in diabetic humans.

Authors:  T J Robinson; J A Archer; K K Gambhir; V W Hollis; L Carter; C Bradley
Journal:  Science       Date:  1979-07-13       Impact factor: 47.728

3.  Demonstration and partial characterization of insulin receptors in human platelets.

Authors:  A S Hajek; J H Joist; R K Baker; L Jarett; W H Daughaday
Journal:  J Clin Invest       Date:  1979-05       Impact factor: 14.808

4.  Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity.

Authors:  P Freychet; J Roth; D M Neville
Journal:  Proc Natl Acad Sci U S A       Date:  1971-08       Impact factor: 11.205
  4 in total
  4 in total

1.  The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects.

Authors:  S L Spinelli; J J O'Brien; S Bancos; G M Lehmann; D L Springer; N Blumberg; C W Francis; M B Taubman; R P Phipps
Journal:  PPAR Res       Date:  2008       Impact factor: 4.964

2.  Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.

Authors:  Samantha F Moore; Christopher M Williams; Edward Brown; Thomas A Blair; Matthew T Harper; Richard J Coward; Alastair W Poole; Ingeborg Hers
Journal:  Cardiovasc Res       Date:  2015-04-22       Impact factor: 10.787

Review 3.  Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation.

Authors:  Tatiana E Suslova; Alexei V Sitozhevskii; Oksana N Ogurkova; Elena S Kravchenko; Irina V Kologrivova; Yana Anfinogenova; Rostislav S Karpov
Journal:  Front Physiol       Date:  2015-01-05       Impact factor: 4.566

Review 4.  Potential Role of Protein Disulfide Isomerase in Metabolic Syndrome-Derived Platelet Hyperactivity.

Authors:  Renato Simões Gaspar; Andrés Trostchansky; Antonio Marcus de Andrade Paes
Journal:  Oxid Med Cell Longev       Date:  2016-12-07       Impact factor: 6.543
  4 in total

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