Literature DB >> 3969553

Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles.

R C Williams, M K Jeffcoat, M L Kaplan, P Goldhaber, H G Johnson, W J Wechter.   

Abstract

The nonsteroidal anti-inflammatory drug, flurbiprofen, a potent cyclooxygenase inhibitor, significantly decreases the resorption of alveolar bone in naturally occurring chronic destructive periodontal disease in beagles. This observation indicates that arachidonic acid metabolites are important in the alveolar bone loss of periodontitis and suggests a use for flurbiprofen in the management of bone resorption disease.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 3969553     DOI： 10.1126/science.3969553

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

1.  Accumulation of non-steroidal anti-inflammatory drugs by gingival fibroblasts.

Authors:  M M Zavarella; O Gbemi; J D Walters
Journal:  J Dent Res       Date:  2006-05       Impact factor: 6.116

Review 2.  Activation and resolution of periodontal inflammation and its systemic impact.

Authors:  Hatice Hasturk; Alpdogan Kantarci
Journal:  Periodontol 2000       Date:  2015-10       Impact factor: 7.589

3.  Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation.

Authors:  R Liu; H S Bal; T Desta; N Krothapalli; M Alyassi; Q Luan; D T Graves
Journal:  J Dent Res       Date:  2006-06       Impact factor: 6.116

4.  Bioavailability of flurbiprofen following buccal administration.

Authors:  D J Stalker; S R Pollock
Journal:  Pharm Res       Date:  1991-05       Impact factor: 4.200

Review 5.  Infection, inflammation, and bone regeneration: a paradoxical relationship.

Authors:  M V Thomas; D A Puleo
Journal:  J Dent Res       Date:  2011-01-19       Impact factor: 6.116

6.  The oral microbiome - an update for oral healthcare professionals.

Authors:  M Kilian; I L C Chapple; M Hannig; P D Marsh; V Meuric; A M L Pedersen; M S Tonetti; W G Wade; E Zaura
Journal:  Br Dent J       Date:  2016-11-18       Impact factor: 1.626

Review 7.  Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs.

Authors:  J E Keeble; P K Moore
Journal:  Br J Pharmacol       Date:  2002-10       Impact factor: 8.739

8.  Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: a proof of concept trial.

Authors:  R Gapski; J L Barr; D P Sarment; M G Layher; S S Socransky; W V Giannobile
Journal:  J Periodontol       Date:  2004-03       Impact factor: 6.993

9.  No effects of piroxicam on osteopenia and recovery after Colles' fracture. A randomized, double-blind, placebo-controlled, prospective trial.

Authors:  P Adolphson; H Abbaszadegan; U Jonsson; N Dalén; H E Sjöberg; S Kalén
Journal:  Arch Orthop Trauma Surg       Date:  1993       Impact factor: 3.067

10.  Bradykinin induces a B2 receptor-mediated calcium signal linked to prostanoid formation in human gingival fibroblasts in vitro.

Authors:  U H Lerner; G Brunius; I Andurén; P O Berggren; L Juntti-Berggren; T Modéer
Journal:  Agents Actions       Date:  1992-09
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.