| Literature DB >> 3969386 |
T C Kwong, J D Sparks, C E Sparks.
Abstract
The plasma protein binding properties of the calcium channel blocker diltiazem were studied using a three-chamber equilibrium dialysis system. Diltiazem is 81% bound to human sera with significant inter-individual variation. The relative binding of diltiazem by lipoproteins and alpha 1-acid glycoprotein was higher than by albumin. The binding to low density lipoprotein was strong and appeared not to be associated with the surface apoprotein.Entities:
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Year: 1985 PMID： 3969386 DOI： 10.3181/00379727-178-2-rc2
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727