Literature DB >> 3968462

Decreased natural killer cell activity in patients with zinc deficiency with sickle cell disease.

E Tapazoglou, A S Prasad, G Hill, G J Brewer, J Kaplan.   

Abstract

Zinc deficiency is associated with depression of a number of immune responses. To assess the relationship of zinc and natural killer activity, we studied natural killer activity in adults with sickle cell disease and in two normal volunteers rendered zinc deficient by dietary restriction. Natural killer activity was significantly lower in patients with sickle cell disease and zinc deficiency (5.1 +/- 2.9 lytic units per 10(6) cells) than in controls (11.7 +/- 5.0 lytic units per 10(6) cells). In the two volunteers, natural killer activity declined during zinc restriction and returned to near initial levels with zinc repletion. These results suggest that zinc deficiency is associated with a lowering of natural killer activity.

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Year:  1985        PMID： 3968462

Source DB:  PubMed          Journal:  J Lab Clin Med        ISSN： 0022-2143


  21 in total

1.  [Effect of zinc substitution on lymphocyte subsets and cellular immune function in hemodialysis patients].

Authors:  W Holtkamp; H P Brodersen; J Thiery; C Falkner; R Bolzius; D Larbig; H E Reis
Journal:  Klin Wochenschr       Date:  1991-06-18

2.  Appraisal of the methodology and applications for measurement of the zinc content of blood components as indicators of zinc status.

Authors:  J C Wallwork
Journal:  Biol Trace Elem Res       Date:  1987-04       Impact factor: 3.738

3.  Improvement of the lymphoproliferative immune response and apoptosis inhibition upon in vitro treatment with zinc of peripheral blood mononuclear cells (PBMC) from HIV+ individuals.

Authors:  I Neves; A L Bertho; V G Veloso; D V Nascimento; D L Campos-Mello; M G Morgado
Journal:  Clin Exp Immunol       Date:  1998-02       Impact factor: 4.330

4.  Plasma zinc levels inversely correlate with vascular cell adhesion molecule-1 concentration in children with sickle cell disease.

Authors:  Solo R Kuvibidila; Manuel Sandoval; Juan Lao; Maria Velez; Lolie Yu; David Ode; Renée Gardner; Gerald Lane; Raj P Warrier
Journal:  J Natl Med Assoc       Date:  2006-08       Impact factor: 1.798

Review 5.  Pharmacotherapeutical strategies in the prevention of acute, vaso-occlusive pain in sickle cell disease: a systematic review.

Authors:  Joep W R Sins; David J Mager; Shyrin C A T Davis; Bart J Biemond; Karin Fijnvandraat
Journal:  Blood Adv       Date:  2017-08-22

6.  Serum thymulin in human zinc deficiency.

Authors:  A S Prasad; S Meftah; J Abdallah; J Kaplan; G J Brewer; J F Bach; M Dardenne
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

Review 7.  Zinc and immunity.

Authors:  A S Prasad
Journal:  Mol Cell Biochem       Date:  1998-11       Impact factor: 3.396

8.  Cefodizime stimulates subpopulations of cells mediating spontaneous or antibody-dependent cytotoxicity in patients with bacterial infections.

Authors:  I O Auer; C Hardörfer; I Zimmermann
Journal:  Infection       Date:  1992       Impact factor: 3.553

9.  Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?

Authors:  Kamolwish Laoprasopwattana; Chonthicha Tangcheewawatthanakul; Wanutsanun Tunyapanit; Rassamee Sangthong
Journal:  PLoS Negl Trop Dis       Date:  2013-06-20

10.  Transport proteins and acute phase reactant proteins in children with sickle cell anemia.

Authors:  R P Warrier; S Kuvibidila; L Gordon; J Humbert
Journal:  J Natl Med Assoc       Date:  1994-01       Impact factor: 1.798
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