Literature DB >> 3967764

Purification of rabbit tumor necrosis factor.

S Abe, T Gatanaga, M Yamazaki, G Soma, D Mizuno.   

Abstract

Rabbit tumor necrosis factor (TNF) was purified and shown by SDS-PAGE to be a single protein of 18 kDa. TNF in 355 ml rabbit serum was precipitated with ammonium sulfate, and purified by repeated DEAE-Sephadex and Sephacryl S-200 chromatographies, and the final fractionation on Blue-Sepharose 6B. By this procedure its yield was 22% and its specific activity was 2.4 X 10(7) U/mg protein. The sequence of the N-terminal 20 amino acids was determined.

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Year:  1985        PMID： 3967764     DOI： 10.1016/0014-5793(85)81071-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK.

Authors:  J L Swantek; M H Cobb; T D Geppert
Journal:  Mol Cell Biol       Date:  1997-11       Impact factor: 4.272

2.  Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

Authors:  X M Sun; W Hsueh
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

3.  Tumor necrosis factor induces glomerular damage in the rabbit.

Authors:  T Bertani; M Abbate; C Zoja; D Corna; N Perico; P Ghezzi; G Remuzzi
Journal:  Am J Pathol       Date:  1989-02       Impact factor: 4.307

4.  Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.

Authors:  C F Nathan
Journal:  J Clin Invest       Date:  1987-12       Impact factor: 14.808

Review 5.  Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation.

Authors:  B Beutler; A Cerami
Journal:  Immunol Res       Date:  1986       Impact factor: 2.829

6.  Endotoxin induction of tumor necrosis factor is enhanced by acid-labile interferon-alpha in acquired immunodeficiency syndrome.

Authors:  A S Lau; J F Livesey
Journal:  J Clin Invest       Date:  1989-09       Impact factor: 14.808

7.  Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients.

Authors:  T Gatanaga; C D Hwang; W Kohr; F Cappuccini; J A Lucci; E W Jeffes; R Lentz; J Tomich; R S Yamamoto; G A Granger
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

8.  Ocular inflammatory effects of intravitreally-injected tumor necrosis factor.

Authors:  J T Rosenbaum; E L Howes; R M Rubin; J R Samples
Journal:  Am J Pathol       Date:  1988-10       Impact factor: 4.307

9.  Effect of soluble P55 tumour-necrosis factor binding fusion protein on the local Shwartzman and Arthus reactions.

Authors:  K E Norman; T J Williams; M Feldmann; A G Rossi
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

10.  Effects of tumour necrosis factor-alpha (TNF-alpha), IL-1 beta and monocytes on lymphokine-activated killer (LAK) induction from natural killer (NK) cells and T lymphocytes.

Authors:  K Yoneda; T Osaki; T Yamamoto; E Ueta
Journal:  Clin Exp Immunol       Date:  1993-08       Impact factor: 4.330
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