Literature DB >> 3967055

Bile acid metabolism during development: metabolism of taurodeoxycholic acid in human fetal liver.

J Gustafsson, S Andersson, J Sjövall.   

Abstract

The metabolism of tauro-[24-14C]deoxycholic acid was studied in microsomal preparations from fetal liver. The livers were obtained at legal abortions performed between week 13 and 24. Taurodeoxycholic acid was efficiently hydroxylated in the 1 beta- and 7 alpha-positions. The hydroxylase activities did not increase with gestational age. A marked variation in extent of hydroxylation was noted between different preparations. The results are discussed in relation to earlier knowledge of fetal and neonatal bile acid metabolism.

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Year:  1985        PMID： 3967055     DOI： 10.1159/000242087

Source DB:  PubMed          Journal:  Biol Neonate        ISSN： 0006-3126


  3 in total

1.  Delta 4-3-oxosteroid 5 beta-reductase deficiency described in identical twins with neonatal hepatitis. A new inborn error in bile acid synthesis.

Authors:  K D Setchell; F J Suchy; M B Welsh; L Zimmer-Nechemias; J Heubi; W F Balistreri
Journal:  J Clin Invest       Date:  1988-12       Impact factor: 14.808

Review 2.  The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.

Authors:  Jiezhong Chen; Kong-Nan Zhao; Chen Chen
Journal:  Ann Transl Med       Date:  2014-01

3.  Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates.

Authors:  Jonas Abdel-Khalik; Thomas Hearn; Alison L Dickson; Peter J Crick; Eylan Yutuc; Karl Austin-Muttitt; Brian W Bigger; Andrew A Morris; Cedric H Shackleton; Peter T Clayton; Takashi Iida; Ria Sircar; Rajat Rohatgi; Hanns-Ulrich Marschall; Jan Sjövall; Ingemar Björkhem; Jonathan G L Mullins; William J Griffiths; Yuqin Wang
Journal:  J Steroid Biochem Mol Biol       Date:  2020-11-24       Impact factor: 4.292
  3 in total

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