Literature DB >> 3965707

Reactivators of organophosphorus-inhibited acetylcholinesterase. 1. Imidazole oxime derivatives.

M M Herrador, J Saénz de Buruaga, M D Suarez.   

Abstract

4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). The in vitro testing revealed that the new compounds are weak reactivators of the phosphorylated electrophorus acetylcholinesterase.

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Year:  1985        PMID: 3965707     DOI: 10.1021/jm00379a026

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  1 in total

1.  Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.

Authors:  Rakesh K Sit; Valery V Fokin; Gabriel Amitai; K Barry Sharpless; Palmer Taylor; Zoran Radić
Journal:  J Med Chem       Date:  2014-02-07       Impact factor: 7.446

  1 in total

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