Literature DB >> 3965696

Influence of fraction unbound upon the renal clearance of furosemide in the isolated perfused rat kidney.

S Hall, M Rowland.   

Abstract

The influence of fraction furosemide unbound (varied over a 28-fold range) upon its renal clearance was studied in an isolated perfused rat kidney, while renal function was maintained. Renal clearance and unbound fraction of furosemide were found to be related linearly, the average unbound renal clearance being 3.3 ml min-1. Urine pH and urine flow rate did not influence furosemide renal clearance in the ranges experienced in this study. Our results are consistent with those predicted from a consideration of the kinetics of renal excretion.

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Year:  1985        PMID： 3965696

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


  16 in total

1.  Response to furosemide during dehydration with and without naproxen pretreatment of kidney donors and renal transplant recipients.

Authors:  P A Sjöström; B G Odlind; M Hammarlund-Udenaes
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

Review 2.  Saturable pharmacokinetics in the renal excretion of drugs.

Authors:  C A van Ginneken; F G Russel
Journal:  Clin Pharmacokinet       Date:  1989-01       Impact factor: 6.447

3.  Effect of neutral endopeptidase inhibition on the natriuresis and renal clearance of atrial natriuretic peptide in perfused rat kidney.

Authors:  M Yamaguchi; Y Hashimoto; H Itoh; K Nakao; K Inui
Journal:  Pharm Res       Date:  1998-09       Impact factor: 4.200

4.  Renal disposition of recombinant human interleukin-11 in the isolated perfused rat kidney.

Authors:  A Takagi; Y Yabe; Y Oka; K Sawai; Y Takakura; M Hashida
Journal:  Pharm Res       Date:  1997-01       Impact factor: 4.200

5.  Renal transport kinetics of furosemide in the isolated perfused rat kidney.

Authors:  L J Lee; J A Cook; D E Smith
Journal:  J Pharmacokinet Biopharm       Date:  1986-04

6.  Plasma protein binding of furosemide in the elderly.

Authors:  G M Pacifici; A Viani; H U Schulz; H J Frercks
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

7.  Changes in renal clearance of furosemide due to changes in renal blood flow and plasma albumin concentration.

Authors:  P A Sjöström; B G Kron; B G Odlind
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

8.  Disposition characteristics of protein drugs in the perfused rat kidney.

Authors:  K Mihara; T Hojo; M Fujikawa; Y Takakura; H Sezaki; M Hashida
Journal:  Pharm Res       Date:  1993-06       Impact factor: 4.200

9.  Physiologically based pharmacokinetic model for the renal clearance of phenolsulfonphthalein and the interaction with probenecid and salicyluric acid in the dog.

Authors:  F G Russel; A C Wouterse; C A van Ginneken
Journal:  J Pharmacokinet Biopharm       Date:  1987-08

10.  Influence of the unbound concentration of cefonicid on its renal elimination in isolated perfused rat kidneys.

Authors:  C A Rodriguez; D E Smith
Journal:  Antimicrob Agents Chemother       Date:  1991-11       Impact factor: 5.191
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