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Literature DB >> 3964537

The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.

J V Watson, J Stewart, G I Evan, A Ritson, K Sikora.

Abstract

A sensitive flow cytometric assay has been developed using a monoclonal antibody, Myc 1-6E10, to quantitate c-myc oncoprotein levels in nuclei isolated from wax embedded testicular tumours. The oncoprotein (p62c-myc) level increased significantly with increasing teratoma differentiation. Patients with intermediate and undifferentiated tumours who developed recurrence had lower p62c-myc levels than those who were disease free since their initial treatment. Such quantitative biochemical methods may provide new prognostic indices for cancer patients.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3964537 PMCID： PMC2001357 DOI： 10.1038/bjc.1986.56

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

30 in total

1. Oncogenes.

Authors: P Hamlyn; K Sikora
Journal: Lancet Date: 1983-08-06 Impact factor: 79.321

Review 2. Cancer genes come of age.

Authors: J M Bishop
Journal: Cell Date: 1983-04 Impact factor: 41.582

3. Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient.

Authors: R Dalla-Favera; F Wong-Staal; R C Gallo
Journal: Nature Date: 1982-09-02 Impact factor: 49.962

4. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.

Authors: D W Hedley; M L Friedlander; I W Taylor; C A Rugg; E A Musgrove
Journal: J Histochem Cytochem Date: 1983-11 Impact factor: 2.479

5. Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas.

Authors: C J Der; G M Cooper
Journal: Cell Date: 1983-01 Impact factor: 41.582

6. Amplification and expression of the c-myc oncogene in human lung cancer cell lines.

Authors: C D Little; M M Nau; D N Carney; A F Gazdar; J D Minna
Journal: Nature Date: 1983 Nov 10-16 Impact factor: 49.962

7. Dual laser beam focussing for flow cytometry through a single crossed cylindrical lens pair.

Authors: J V Watson
Journal: Cytometry Date: 1981-07

8. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.

Authors: M Schwab; K Alitalo; K H Klempnauer; H E Varmus; J M Bishop; F Gilbert; G Brodeur; M Goldstein; J Trent
Journal: Nature Date: 1983 Sep 15-21 Impact factor: 49.962

Review 9. The emerging genetics of human cancer.

Authors: T G Krontiris
Journal: N Engl J Med Date: 1983-08-18 Impact factor: 91.245

10. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Authors: G I Evan; G K Lewis; G Ramsay; J M Bishop
Journal: Mol Cell Biol Date: 1985-12 Impact factor: 4.272

14 in total

Review 1. Demystified ... oncogenes.

Authors: Y L Wallis; F Macdonald
Journal: Mol Pathol Date: 1999-04

Review 10. Germ cell tumour chemotherapy.

Authors: A Horwich
Journal: Br J Cancer Date: 1989-02 Impact factor: 7.640

The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.

1. Oncogenes.

Review 2. Cancer genes come of age.

3. Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient.

4. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.

5. Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas.

6. Amplification and expression of the c-myc oncogene in human lung cancer cell lines.

7. Dual laser beam focussing for flow cytometry through a single crossed cylindrical lens pair.

8. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.

Review 9. The emerging genetics of human cancer.

10. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Review 1. Demystified ... oncogenes.

2. Abnormal distribution of c-myc oncogene product in familial adenomatous polyposis.

3. c-myc oncoprotein levels in bladder cancer.

Review 4. Oncogenes and urological malignancies: implications for the future.

5. c-myc, p53, and Bcl-2 expression and clinical outcome in uveal melanoma.

6. The expression of c-myc, bcl-2 and p53 proteins in adenocarcinomas of lung.

Review 7. Molecular biology of testicular germ cell tumors: current status.

8. C-myc oncogene product P62c-myc in ovarian mucinous neoplasms: immunohistochemical study correlated with malignancy.

Review 9. Changes in c-onc expression during embryonal carcinoma cell differentiation.

Review 10. Germ cell tumour chemotherapy.