Literature DB >> 3964260

H1-histaminergic activation stimulates inositol-1-phosphate accumulation in chromaffin cells.

E P Noble, M Bommer, E Sincini, T Costa, A Herz.   

Abstract

Adrenal medullary chromaffin cells maintained in vitro were prelabeled with [3H]inositol and the accumulation of [3H]inositol-1-phosphate, was determined following stimulation with a variety of pharmacological agents. Carbachol, bradykinin, and histamine produced significantly greater accumulation of [3H] inositol-1-phosphate over basal levels, with histamine producing the greatest effect. H1-histamine receptor antagonists, mepyramine, pyrilamine, tripelennamine and clemastine were all able to reduce or completely block the histamine response. The two specific H2-histamine receptor antagonists, cimetidine and ranitidine, had no effect on this response. Histamine dose-response characteristics in the presence of mepyramine and clemastine suggest the H1 antagonism to be competitive in nature.

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Year:  1986        PMID： 3964260     DOI： 10.1016/0006-291x(86)90031-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Agonist-dependent patterns of cytosolic Ca2+ changes in single bovine adrenal chromaffin cells: relationship to catecholamine release.

Authors:  K A Stauderman; M M Murawsky; R M Pruss
Journal:  Cell Regul       Date:  1990-08

2.  Histamine-induced increases in cyclic AMP levels in bovine adrenal medullary cells.

Authors:  P D Marley; K A Thomson; K Jachno; M J Johnston
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

3.  Oscillatory activation of calcium-dependent potassium channels in HeLa cells induced by histamine H1 receptor stimulation: a single-channel study.

Authors:  R Sauvé; C Simoneau; L Parent; R Monette; G Roy
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

4.  Histamine promotes excitability in bovine adrenal chromaffin cells by inhibiting an M-current.

Authors:  Damian J Wallace; Chen Chen; Philip D Marley
Journal:  J Physiol       Date:  2002-05-01       Impact factor: 5.182

5.  Single-channel and Fura-2 analysis of internal Ca2+ oscillations in HeLa cells: contribution of the receptor-evoked Ca2+ influx and effect of internal pH.

Authors:  R Sauvé; A Diarra; M Chahine; C Simoneau; L Garneau; G Roy
Journal:  Pflugers Arch       Date:  1990-04       Impact factor: 3.657

6.  Small-conductance Ca(2+)-activated K+ channels in bovine chromaffin cells.

Authors:  A R Artalejo; A G García; E Neher
Journal:  Pflugers Arch       Date:  1993-04       Impact factor: 3.657

7.  Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway.

Authors:  Carol Hamelink; Hyeon-Woo Lee; Yun Chen; Maurizio Grimaldi; Lee E Eiden
Journal:  J Neurosci       Date:  2002-07-01       Impact factor: 6.167
  7 in total

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