| Literature DB >> 3961677 |
I Nikolov, V D Rogozkin, T Pantev, K S Chertkov, E A Dikovenko, S A Davidova.
Abstract
The radioprotective effect of the Bulgarian drug Adeturone was tested on prolonged irradiated monkeys. The animals were gamma-irradiated (137Cs) in a dose of 8.3 Gy (exposure rate 3.95 X 10(-3) mA.kg-1; (0.92 R.min-1]. Adeturone, given by i.v. injection at a dose of 100 mg.kg-1 body weight according to a pre- and postradiation scheme will afford protection to monkeys by ensuring 50% survival and mitigating the severity of some symptoms of radiation disease. A similar effect was obtained with ATP-administration by two i.m. injections of 37 mg.kg-1 body weight. The survival in control group was only 5% (LD95/45).Entities:
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Year: 1986 PMID： 3961677
Source DB: PubMed Journal: Strahlenther Onkol ISSN： 0179-7158 Impact factor: 3.621