Literature DB >> 3960

Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction.

C H Shatney, D J MacCarter, R C Lillehei.   

Abstract

With use of a canine model of occlusion of the left anterior descending coronary artery and an intracellular lactic dehydrogenase stain to measure infarct size directly, the effects of allopurinol, methylprednisolone sodium succinate and propranolol were studied. Allopurinol did not influence the extent of myocardial necrosis, whereas both methylprednisolone and propranolol significantly reduced myocardial infarct size. Possible mechanisms of action and clinical applicability of these agents are discussed.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 3960     DOI： 10.1016/0002-9149(76)90398-2

Source DB:  PubMed          Journal:  Am J Cardiol        ISSN： 0002-9149            Impact factor:   2.778


  20 in total

1.  Requiem for Richard Lillehei.

Authors:  John C. Norman
Journal:  Cardiovasc Dis       Date:  1981-06

2.  Determinants of infarct size in non-human primates.

Authors:  W Flameng; E Lesaffre; J Vanhaecke
Journal:  Basic Res Cardiol       Date:  1990 Jul-Aug       Impact factor: 17.165

3.  Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.

Authors:  Maciej Owecki; Jerzy Sowiński
Journal:  Pharm World Sci       Date:  2006-06-22

4.  Massive doses of methylprednisolone (30 mg/kg) in man: immediate haemodynamic effects in "low output state".

Authors:  S Piepenbrock; G Hempelmann; C Westermann
Journal:  Intensive Care Med       Date:  1977-08       Impact factor: 17.440

5.  Effects of propranolol on regional myocardial function, electrograms, and blood flow in conscious dogs with myocardial ischemia.

Authors:  S F Vatner; H Baig; W T Manders; H Ochs; M Pagani
Journal:  J Clin Invest       Date:  1977-08       Impact factor: 14.808

6.  Prevention by chlorpromazine of ischemic liver cell death.

Authors:  K R Chien; J Abrams; R G Pfau; J L Farber
Journal:  Am J Pathol       Date:  1977-09       Impact factor: 4.307

7.  Effect of early treatment with propranolol on left ventricular function four weeks after myocardial infarction.

Authors:  M A Brown; R M Norris; P F Barnaby; G G Geary; P W Brandt
Journal:  Br Heart J       Date:  1985-10

8.  Comparative investigation of the effects of metoprolol, propranolol, practolol, and verapamil in the acute phase of experimental myocardial infarction.

Authors:  W Bernauer
Journal:  Klin Wochenschr       Date:  1982-01-15

9.  Ibuprofen inhibits granulocyte responses to inflammatory mediators. A proposed mechanism for reduction of experimental myocardial infarct size.

Authors:  P J Flynn; W K Becker; G M Vercellotti; D J Weisdorf; P R Craddock; D E Hammerschmidt; R C Lillehei; H S Jacob
Journal:  Inflammation       Date:  1984-03       Impact factor: 4.092

10.  Effect of propranolol on enzymatic and histochemical estimates of infarct size in experimental myocardial infarction.

Authors:  G J Jesmok; D C Warltier; G J Gross; H F Hardman
Journal:  Basic Res Cardiol       Date:  1978 Nov-Dec       Impact factor: 17.165
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.