Literature DB >> 3956922

Dissolution of cholesterol gallstones: comparison of solvents.

L L Lee, J P McGahan.   

Abstract

Various gallstone solvents are compared to evaluate their efficacy. Cholesterol gallstones from 5 patients were weight matched and incubated in 5 different solutions at 37 degrees C. These solutions consisted of methyl-tertiary butyl ether (MTBE), 90% mono-octanoin (MO), absolute alcohol, normal saline, and water. Absolute alcohol and MTBE were found to induce faster stone dissolution than the mono-octanoin derivative. Concentrations of alcohol below 80%, normal saline, and water were not effective in dissolving stones. Newer agents such as MTBE may prove valuable in dissolution of stones in the human gallbladder or bile ducts.

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Year:  1986        PMID： 3956922     DOI： 10.1007/bf02035062

Source DB:  PubMed          Journal:  Gastrointest Radiol        ISSN： 0364-2356


  8 in total

1.  Unusual cholesterol solubility in water/glyceryl-1-monooctanoate solutions.

Authors:  J B Bogardus
Journal:  J Pharm Sci       Date:  1982-03       Impact factor: 3.534

2.  Biochemical and morphological investigations of the toxicity of a Capmul preparation and a bile salt-EDTA solution in patients with bile duct stones.

Authors:  U Leuschner; H Baumgärtel; R David; C M Kirchmaier; F Hagenmüller; J Sieratzki; K Hübner
Journal:  Am J Gastroenterol       Date:  1984-04       Impact factor: 10.864

3.  In vitro dissolution of gallstones: comparison of monooctanoin, sodium dehydrocholate, heparin, and saline.

Authors:  S K Teplick; C A Pavlides; L R Goodman; V K Babayan
Journal:  AJR Am J Roentgenol       Date:  1982-02       Impact factor: 3.959

4.  Retained biliary tract stones. Nonsurgical treatment with capmul 8210, a new cholesterol gallstone dissolution agent.

Authors:  E Mack; E M Patzer; A B Crummy; A F Hofmann; V K Babayan
Journal:  Arch Surg       Date:  1981-03

5.  Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application.

Authors:  J L Thistle; G L Carlson; A F Hofmann; N F LaRusso; R L MacCarty; G L Flynn; W I Higuchi; V K Babayan
Journal:  Gastroenterology       Date:  1980-05       Impact factor: 22.682

6.  Cholesterol solubility in organic solvents.

Authors:  G L Flynn; Y Shah; S Prakongpan; K H Kwan; W I Higuchi; A F Hofmann
Journal:  J Pharm Sci       Date:  1979-09       Impact factor: 3.534

7.  The effect of monooctanoin on retained common duct stones.

Authors:  T R Gadacz
Journal:  Surgery       Date:  1981-05       Impact factor: 3.982

8.  Effects of alcohol on the pyloric sphincter.

Authors:  K Phaosawasdi; R Tolin; E Mayer; R S Fisher
Journal:  Dig Dis Sci       Date:  1979-12       Impact factor: 3.199
  8 in total

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