Literature DB >> 3956697

Cellular and secreted tumor plasminogen activator: the effects of NaCl.

P Badenoch-Jones, I A Ramshaw, A Grant.   

Abstract

Plasminogen activator, secreted by metastatic tumor cells, was strongly inhibited in buffer or tissue culture medium containing physiological concentrations of NaCl. Intact cells, however, expressed strong activity under similar conditions. Thus, if plasminogen activator is involved in invasion and metastasis, the cellular activity, acting as an ectoenzyme, may be more important than secreted enzyme under physiological conditions.

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Year:  1986        PMID: 3956697     DOI: 10.1007/bf02118645

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  17 in total

1.  Plasminogen activator from cells transformed by an oncogenic virus: inhibitors of the activation reaction.

Authors:  K Danø; E Reich
Journal:  Biochim Biophys Acta       Date:  1979-01-12

2.  Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor.

Authors:  H A Chapman; Z Vavrin; J B Hibbs
Journal:  Cell       Date:  1982-03       Impact factor: 41.582

3.  Involvement of plasminogen activator production with tumor metastasis in a rat model.

Authors:  S A Carlsen; I A Ramshaw; R C Warrington
Journal:  Cancer Res       Date:  1984-07       Impact factor: 12.701

4.  In vitro characteristics of metastatic variant subclones of restricted genetic origin.

Authors:  J E Talmadge; J R Starkey; D R Stanford
Journal:  J Supramol Struct Cell Biochem       Date:  1981

5.  Importance, localization and functional properties of the cell-associated form of plasminogen activator in mouse peritoneal macrophages.

Authors:  G Lemaire; J C Drapier; J F Petit
Journal:  Biochim Biophys Acta       Date:  1983-02-22

Review 6.  Cancer metastasis. Organ colonization and the cell-surface properties of malignant cells.

Authors:  G L Nicolson
Journal:  Biochim Biophys Acta       Date:  1982-12-21

7.  Plasminogen activators as markers of tumor colonization potential.

Authors:  R Ng; J A Kellen; A C Wong
Journal:  Invasion Metastasis       Date:  1983

8.  Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines.

Authors:  B S Wang; G A McLoughlin; J P Richie; J A Mannick
Journal:  Cancer Res       Date:  1980-02       Impact factor: 12.701

9.  An inhibitor of plasminogen activator produced by tumour cell fusion hybrids.

Authors:  P Badenoch-Jones; I A Ramshaw; A Grant
Journal:  Aust J Exp Biol Med Sci       Date:  1985-06

10.  Quantitation of fibrinolytic activity of Syrian hamster fibroblasts using 3H-labeled fibrinogen prepared by reductive alkylation.

Authors:  J C Barrett; B D Crawford; P O Ts'o
Journal:  Cancer Res       Date:  1977-04       Impact factor: 12.701

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