Literature DB >> 3955301

Evidence for the existence of 5-hydroxytryptamine receptors, which are not of the 5-HT2 type, mediating contraction of rabbit isolated basilar artery.

P B Bradley, P P Humphrey, R H Williams.   

Abstract

In the rabbit isolated basilar artery the contractile action of 5-hydroxytryptamine (5-HT) was little affected by high concentrations of ketanserin (1.0 X 10(-6) M) indicating that 5-HT-receptors other than those of the 5-HT2-type were involved. The contractile action of 5-HT was mimicked by methysergide and 5-carboxamidotryptamine (5-CT) with equipotent concentration ratios (5-HT = 1) of about 22 and 0.6 respectively. This profile is characteristic of that in the dog saphenous vein which contains a 5-HT receptor type that may be described as '5-HT1-like'.

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Year:  1986        PMID： 3955301      PMCID： PMC1916912          DOI： 10.1111/j.1476-5381.1986.tb10149.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

Review 1.  Peripheral 5-hydroxytryptamine receptors and their classification.

Authors:  P P Humphrey
Journal:  Neuropharmacology       Date:  1984-12       Impact factor: 5.250

2.  Evidence for two types of excitatory receptor for 5-hydroxytryptamine in dog isolated vasculature.

Authors:  E Apperley; W Feniuk; P P Humphrey; G P Levy
Journal:  Br J Pharmacol       Date:  1980-02       Impact factor: 8.739

3.  Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.

Authors:  J M Van Nueten; P A Janssen; J Van Beek; R Xhonneux; T J Verbeuren; P M Vanhoutte
Journal:  J Pharmacol Exp Ther       Date:  1981-07       Impact factor: 4.030

4.  Analysis of the 5-hydroxytryptamine induced contraction of the human basilar arterial strip compared with the rat aortic strip in vitro.

Authors:  C Forster; E T Whalley
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-04       Impact factor: 3.000

5.  Serotonin-induced contraction of canine basilar artery: mediation by 5-HT1 receptors.

Authors:  S J Peroutka; M Noguchi; D J Tolner; G S Allen
Journal:  Brain Res       Date:  1983-01-24       Impact factor: 3.252

6.  Evidence for mediation by 5-HT2 receptors of 5-hydroxytryptamine-induced contraction of canine basilar artery.

Authors:  E Müller-Schweinitzer; G Engel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-12       Impact factor: 3.000

7.  A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists.

Authors:  W Feniuk; P P Humphrey; M J Perren; A D Watts
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

8.  Tryptamine-induced vasoconstrictor responses in rat caudal arteries are mediated predominantly via 5-hydroxytryptamine receptors.

Authors:  P B Bradley; P P Humphrey; R H Williams
Journal:  Br J Pharmacol       Date:  1985-04       Impact factor: 8.739

9.  Indoleaminergic mechanisms in brain vessels; localization, concentration, uptake and in vitro responses of 5-hydroxytryptamine.

Authors:  L Edvinsson; E Birath; R Uddman; T J Lee; D Duverger; E T MacKenzie; B Scatton
Journal:  Acta Physiol Scand       Date:  1984-07
  9 in total
  11 in total

1.  Comparison of the effects of cromakalim, a potassium conductance enhancer, and nimodipine, a calcium antagonist, on 5-hydroxytryptamine responses in a variety of vascular smooth muscle preparations.

Authors:  C R Cain; C D Nicholson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-09       Impact factor: 3.000

2.  Investigations of cardiovascular 5-hydroxytryptamine receptor subtypes in the rat.

Authors:  J R Docherty
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-01       Impact factor: 3.000

3.  The tail wags the dog: possible mechanism for reverse allosteric control of ligand-activated channels.

Authors:  E Vardy; T Kenakin
Journal:  Br J Pharmacol       Date:  2014-04       Impact factor: 8.739

4.  Characterization of 5-HT receptors mediating contraction of canine and primate basilar artery by use of GR43175, a selective 5-HT1-like receptor agonist.

Authors:  H E Connor; W Feniuk; P P Humphrey
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

5.  5-hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction.

Authors:  A H Clark; C J Garland
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

6.  5-HT1-like receptors requiring functional cyclo-oxygenase and 5-HT2 receptors independent of cyclo-oxygenase mediate contraction of the human umbilical artery.

Authors:  S J MacLennan; M J Whittle; J C McGrath
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

7.  Influence of the endothelium on contractile effects of 5-hydroxytryptamine and selective 5-HT agonists in canine basilar artery.

Authors:  H E Connor; W Feniuk
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

8.  5-HT1-like and 5-HT2A receptors mediate 5-hydroxytryptamine-induced contraction of rabbit isolated mesenteric artery.

Authors:  O Yildiz; M Tuncer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-08       Impact factor: 3.000

9.  Differential classification of vascular smooth muscle and endothelial cell 5-HT receptors by use of tryptamine analogues.

Authors:  P Leff; G R Martin; J M Morse
Journal:  Br J Pharmacol       Date:  1987-06       Impact factor: 8.739

10.  Effects of 5-hydroxytryptamine on human isolated placental chorionic arteries and veins.

Authors:  J Reviriego; J Marín
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739
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