Literature DB >> 3955053

Kinetics of inhibition of rat liver and kidney arginases by proline and branched-chain amino acids.

N Carvajal, S D Cederbaum.   

Abstract

The effects of proline, leucine, isoleucine and valine on kidney and liver arginases were studied. At pH 7.5 and at nearly physiological concentrations, the branched-chain amino acids caused a significant inhibition of liver arginase A1 and only minor effects on kidney arginase A4. Kidney arginase was, however, much more sensitive to inhibition by proline than the liver enzyme. The inhibition of liver and kidney arginases by branched-chain amino acids was partial, indicating the existence of allosteric sites on both enzymes. The function of kidney arginase in proline biosynthesis and a possible role of branched-chain amino acids in the hydrolysis of arginine in liver is discussed.

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Year:  1986        PMID： 3955053     DOI： 10.1016/0167-4838(86)90219-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  Molecular genetic study of human arginase deficiency.

Authors:  W W Grody; D Klein; A E Dodson; R M Kern; P B Wissmann; B K Goodman; P Bassand; B Marescau; S S Kang; J V Leonard
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025

2.  Differential expression of the two human arginase genes in hyperargininemia. Enzymatic, pathologic, and molecular analysis.

Authors:  W W Grody; C Argyle; R M Kern; G J Dizikes; E B Spector; A D Strickland; D Klein; S D Cederbaum
Journal:  J Clin Invest       Date:  1989-02       Impact factor: 14.808

3.  Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme.

Authors:  W W Grody; R M Kern; D Klein; A E Dodson; P B Wissman; S H Barsky; S D Cederbaum
Journal:  Hum Genet       Date:  1993-03       Impact factor: 4.132

4.  Urea production by kidney collecting ducts in vitro: effect of amino acid addition.

Authors:  O Levillain; A Hus-Citharel; F Morel
Journal:  Pflugers Arch       Date:  1994-04       Impact factor: 3.657

5.  Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.

Authors:  Jennifer M Fitzpatrick; Jose M Fuentes; Iain W Chalmers; Thomas A Wynn; Manuel Modolell; Karl F Hoffmann; Matthias Hesse
Journal:  Int J Parasitol       Date:  2008-08-06       Impact factor: 3.981

6.  Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation.

Authors:  Daniela Bruch-Gerharz; Oliver Schnorr; Christoph Suschek; Karl-Friedrich Beck; Josef Pfeilschifter; Thomas Ruzicka; Victoria Kolb-Bachofen
Journal:  Am J Pathol       Date:  2003-01       Impact factor: 4.307

7.  Selective endothelial overexpression of arginase II induces endothelial dysfunction and hypertension and enhances atherosclerosis in mice.

Authors:  Boris L Vaisman; Karen L Andrews; Sacha M L Khong; Katherine C Wood; Xiao L Moore; Yi Fu; Diane M Kepka-Lenhart; Sidney M Morris; Alan T Remaley; Jaye P F Chin-Dusting
Journal:  PLoS One       Date:  2012-07-19       Impact factor: 3.240

8.  New Insights into the Determinants of Specificity in Human Type I Arginase: Generation of a Mutant That Is Only Active with Agmatine as Substrate.

Authors:  María-Soledad Orellana; Gonzalo A Jaña; Maximiliano Figueroa; José Martínez-Oyanedel; Fabiola E Medina; Estefanía Tarifeño-Saldivia; Marcell Gatica; María Ángeles García-Robles; Nelson Carvajal; Elena Uribe
Journal:  Int J Mol Sci       Date:  2022-06-09       Impact factor: 6.208

9.  Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites.

Authors:  Rui Pang; Hua Zhou; Yifeng Huang; Yubin Su; Xinhai Chen
Journal:  Front Immunol       Date:  2020-07-28       Impact factor: 7.561
  9 in total

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