Literature DB >> 3954968

Lymphocyte doubling time in chronic lymphocytic leukaemia: analysis of its prognostic significance.

E Montserrat, J Sanchez-Bisono, N Viñolas, C Rozman.   

Abstract

In 100 untreated patients with chronic lymphocytic leukaemia (CLL) lymphocyte doubling time (LDT) has been investigated in relationship with clinical stages, bone marrow histological patterns, treatment-free period and survival. Although partially correlated with clinical stages and bone marrow patterns, LDT has a clear prognostic significance by itself: whereas a LDT of 12 or less months identifies a population of patients with poor prognosis, a LDT higher than 12 months is indicative of good prognosis as substantiated by a long treatment-free period and survival. This simple parameter can be useful in the clinical management of CLL patients.

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Year:  1986        PMID： 3954968     DOI： 10.1111/j.1365-2141.1986.tb02969.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  34 in total

1.  Immunoglobulin mutational status detected through single-round amplification of partial V(H) region represents a good prognostic marker for clinical outcome in chronic lymphocytic leukemia.

Authors:  Roberto Marasca; Rossana Maffei; Monica Morselli; Patrizia Zucchini; Ilaria Castelli; Silvia Martinelli; Marcella Fontana; Sara Ravanetti; Monica Curotti; Giovanna Leonardi; Katia Cagossi; Giovanni Partesotti; Giuseppe Torelli
Journal:  J Mol Diagn       Date:  2005-11       Impact factor: 5.568

2.  In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells.

Authors:  Bradley T Messmer; Davorka Messmer; Steven L Allen; Jonathan E Kolitz; Prasad Kudalkar; Denise Cesar; Elizabeth J Murphy; Prasad Koduru; Manlio Ferrarini; Simona Zupo; Giovanna Cutrona; Rajendra N Damle; Tarun Wasil; Kanti R Rai; Marc K Hellerstein; Nicholas Chiorazzi
Journal:  J Clin Invest       Date:  2005-03       Impact factor: 14.808

3.  Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients.

Authors:  Michaël Van Damme; Emerence Crompot; Nathalie Meuleman; Philippe Mineur; Barbara Dessars; Hakim El Housni; Dominique Bron; Laurence Lagneaux; Basile Stamatopoulos
Journal:  Epigenetics       Date:  2014-10       Impact factor: 4.528

4.  Chronic lymphocytic leukemia: from molecular pathogenesis to novel therapeutic strategies.

Authors:  Julio Delgado; Ferran Nadeu; Dolors Colomer; Elias Campo
Journal:  Haematologica       Date:  2020-07-02       Impact factor: 9.941

Review 5.  Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells.

Authors:  Rajendra N Damle; Carlo Calissano; Nicholas Chiorazzi
Journal:  Best Pract Res Clin Haematol       Date:  2010-03       Impact factor: 3.020

6.  Prognostic relevance of serum levels and cellular expression of adiponectin in B-cell chronic lymphocytic leukemia.

Authors:  Stefano Molica; Gaetano Vitelli; Giovanna Cutrona; Katia Todoerti; Rosanna Mirabelli; Giovanna Digiesi; Diana Giannarelli; Isabella Sperduti; Matteo Molica; Massimo Gentile; Fortunato Morabito; Antonino Neri; Manlio Ferrarini
Journal:  Int J Hematol       Date:  2008-09-27       Impact factor: 2.490

Review 7.  Evolving Strategies for the Treatment of Chronic Lymphocytic Leukemia in the Upfront Setting.

Authors:  Spencer H Bachow; Nicole Lamanna
Journal:  Curr Hematol Malig Rep       Date:  2016-02       Impact factor: 3.952

Review 8.  Advances in the understanding of biology and prognosis in chronic lymphocytic leukemia.

Authors:  Clive S Zent; Neil E Kay
Journal:  Curr Oncol Rep       Date:  2004-09       Impact factor: 5.075

9.  A molecular score by quantitative PCR as a new prognostic tool at diagnosis for chronic lymphocytic leukemia patients.

Authors:  Basile Stamatopoulos; Nathalie Meuleman; Cécile De Bruyn; Karlien Pieters; Géraldine Anthoine; Philippe Mineur; Dominique Bron; Laurence Lagneaux
Journal:  PLoS One       Date:  2010-09-16       Impact factor: 3.240

10.  Clinicoprognostic implications of increased serum levels of vascular endothelial growth factor and basic fibroblastic growth factor in early B-cell chronic lymphocytic leukaemia.

Authors:  S Molica; G Vitelli; D Levato; A Ricciotti; G Digiesi
Journal:  Br J Cancer       Date:  2002-01-07       Impact factor: 7.640
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