[Pupillometry in psychopharmacologic experiments].

Considering data of various clinical pharmacological studies, in which computer-assisted pupillometry was utilized, we investigated the following questions: What are the effects of drugs of 7 psychopharmacological classes on the human pupil? Do dose-efficacy and time-efficacy curves based on pupillary variables provide cues about pharmacodynamic properties of psychotropic substances? Is there a relationship between pupillometric and critical flicker frequency measures? Is there a relation between pupillometric and quantitative electroencephalographic changes? Are there correlations between static pupillometric and pharmacokinetic (e.g. blood levels) variables? Our investigations demonstrated that static pupillometry-utilized in the described manner and under certain experimental conditions - provide valuable information about effects of psychotropic drugs on the central and autonomous nervous system.

RCT Entities:   Population Interventions Outcomes