Literature DB >> 395158

Genotypic characterization and clinical evaluation of an influenza A/Texas/1/77 (H3N2)-like recombinant: RIT 4199.

G Florent, A Hay, M Lobmann, D Jovanovic, A Dalem.   

Abstract

The RIT 4199 (H3N2) strain was obtained by recombination of PR/8/34 (H0N1) and A/Alaska/5/77 (H3N2) isolates. Its genetic composition was determined by RNA-RNA hybridization and by identification by gel electrophoresis of the double-standard RNA formed. The RIT 4199 was inoculated intranasally to 27 seronegative volunteers at a dose of 10(7.3)EID50. The results show that it is suitable for live vaccine strain.

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Year:  1979        PMID： 395158     DOI： 10.1016/s0092-1157(79)80010-4

Source DB:  PubMed          Journal:  J Biol Stand        ISSN： 0092-1157


  2 in total

1.  Recombinants of influenza virus type B as potential live vaccine candidates: RNA characterization and evaluation in man.

Authors:  M Lobmann; A Delem; D Jovanovic; J Peetermans
Journal:  J Hyg (Lond)       Date:  1981-08

2.  Preparation of genetically engineered A/H5N1 and A/H7N1 pandemic vaccine viruses by reverse genetics in a mixture of Vero and chicken embryo cells.

Authors:  Isabelle Legastelois; Adolfo Garcia-Sastre; Peter Palese; Terrence M Tumpey; Taronna R Maines; Jacqueline M Katz; Frederick R Vogel; Catherine Moste
Journal:  Influenza Other Respir Viruses       Date:  2007-05       Impact factor: 4.380
  2 in total

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