Literature DB >> 3951324

Liquid chromatographic assay for cerebrospinal fluid serotonin.

M Linnoila, K A Jacobson, T H Marshall, T L Miller, K L Kirk.   

Abstract

A novel liquid chromatographic method was developed for accurate and precise routine quantification of serotonin in human cerebrospinal fluid. Serotonin is derivatized with an amine-specific reagent leaving its hydroxy group free for electrochemical detection and making it lipophilic enough for efficient extraction into organic solvents. The method is reproducible, linear and free of interferences by endogenous amines other than serotonin. The limit of sensitivity is 100 fmol/ml CSF or 20 parts per trillion. Serotonin concentrations in lumbar cerebrospinal fluid from drug free, depressed patients were in the low nanomolar range.

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Year:  1986        PMID： 3951324      PMCID： PMC5979267          DOI： 10.1016/0024-3205(86)90582-5

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  13 in total

1.  Effect of diet on urinary MHPG excretion in depressed patients and normal control subjects.

Authors:  G Muscettola; T Wehr; F K Goodwin
Journal:  Am J Psychiatry       Date:  1977-08       Impact factor: 18.112

2.  Serotonin and 5-hydroxyindoleacetic acid in CSF. Difference in Parkinson's disease and dementia of the Alzheimer's type.

Authors:  L Volicer; L K Direnfeld; M Freedman; M L Albert; P J Langlias; E D Bird
Journal:  Arch Neurol       Date:  1985-02

3.  [A new method for synthesis of peptides: activation of the carboxyl group with dicyclohexylcarbodiimide using 1-hydroxybenzotriazoles as additives].

Authors:  W König; R Geiger
Journal:  Chem Ber       Date:  1970

4.  Diurnal rhythms of serotonin in monkey cerebrospinal fluid.

Authors:  P L Taylor; N A Garrick; R S Burns; L Tamarkin; D L Murphy; S P Markey
Journal:  Life Sci       Date:  1982-11-01       Impact factor: 5.037

5.  Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.

Authors:  N H Neef; T N Tozer; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1967-11       Impact factor: 4.030

6.  5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor?

Authors:  M Asberg; L Träskman; P Thorén
Journal:  Arch Gen Psychiatry       Date:  1976-10

7.  Efficient extraction and mass spectrometric assay of serotonin in biological fluids.

Authors:  S P Markey; R W Colburn; J N Johannessen
Journal:  Biomed Mass Spectrom       Date:  1981-07

8.  Kinetics of drug-induced changes in dopamine and serotonin metabolite concentrations in the CSF of the rat.

Authors:  E Mignot; D Laude; J L Elghozi
Journal:  J Neurochem       Date:  1984-03       Impact factor: 5.372

Review 9.  Cerebrospinal fluid probenecid studies: a reinterpretation.

Authors:  R W Cowdry; M H Ebert; D P van Kammen; R M Post; F K Goodwin
Journal:  Biol Psychiatry       Date:  1983-11       Impact factor: 13.382

10.  Alcohol and central serotonin metabolism in man.

Authors:  J C Ballenger; F K Goodwin; L F Major; G L Brown
Journal:  Arch Gen Psychiatry       Date:  1979-02
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  4 in total

1.  Analysis of equine cisterna magna cerebrospinal fluid for the presence of some monoamine neurotransmitters and transmitter metabolites.

Authors:  D M Vaughn; G B Smyth; W L Whitmer; C Satjawatcharaphong
Journal:  Vet Res Commun       Date:  1989       Impact factor: 2.459

2.  Terminal processes of serotonin neurons in the caudal spinal cord of the molly, Poecilia latipinna, project to the leptomeninges and urophysis.

Authors:  S L Cohen; R M Kriebel
Journal:  Cell Tissue Res       Date:  1989-03       Impact factor: 5.249

3.  Liquid chromatographic assay for cerebrospinal fluid normetanephrine.

Authors:  T H Marshall; K A Jacobson; K L Kirk; M Linnoila
Journal:  Life Sci       Date:  1987-04-13       Impact factor: 5.037

4.  Cerebrospinal fluid concentrations of neuropeptide Y in depressed patients and in controls.

Authors:  A Gjerris; E Widerlöv; L Werdelin; R Ekman
Journal:  J Psychiatry Neurosci       Date:  1992-03       Impact factor: 6.186
  4 in total

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