Literature DB >> 3949761

Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization.

A Abbruzzese, M H Park, J E Folk.   

Abstract

Deoxyhypusine hydroxylase, the enzyme that catalyzes the formation of hypusine from deoxyhypusine in eukaryotic initiation factor 4D, has been partially purified from rat testis. The partially purified enzyme requires only the addition of certain sulfhydryl compounds for catalytic activity, dithiothreitol being the most effective. Its lack of dependency on the alpha-keto acid-dependent dioxygenase cofactors, Fe2+, alpha-ketoglutarate, and ascorbic acid, its failure to decarboxylate stoichiometrically alpha-ketoglutarate with deoxyhypusine hydroxylation, and its strong and specific inhibition by Fe2+ all suggest a catalytic mechanism of this enzyme unlike that of the prolyl and lysyl hydroxylases.

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Year:  1986        PMID： 3949761

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  41 in total

1.  Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme.

Authors:  Jong-Hwan Park; L Aravind; Edith C Wolff; Jörn Kaevel; Yeon Sook Kim; Myung Hee Park
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-21       Impact factor: 11.205

2.  The polyamine-derived amino acid hypusine: its post-translational formation in eIF-5A and its role in cell proliferation.

Authors:  M H Park; Y A Joe; K R Kang; Y B Lee; E C Wolff
Journal:  Amino Acids       Date:  1996-06       Impact factor: 3.520

3.  Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani.

Authors:  Bhavna Chawla; Anupam Jhingran; Sushma Singh; Nidhi Tyagi; Myung Hee Park; N Srinivasan; Sigrid C Roberts; Rentala Madhubala
Journal:  J Biol Chem       Date:  2009-10-30       Impact factor: 5.157

4.  Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD.

Authors:  C H Lee; P Y Um; M H Park
Journal:  Biochem J       Date:  2001-05-01       Impact factor: 3.857

5.  Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis.

Authors:  Yoon Lee; Hyun-Kyung Kim; Hyo-Eun Park; Myung Hee Park; Young Ae Joe
Journal:  Mol Cell Biochem       Date:  2002-08       Impact factor: 3.396

Review 6.  Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.

Authors:  E C Wolff; K R Kang; Y S Kim; M H Park
Journal:  Amino Acids       Date:  2007-05-04       Impact factor: 3.520

7.  Evidence for conformational changes in the yeast deoxyhypusine hydroxylase Lia1 upon iron displacement from its active site.

Authors:  Veridiana S P Cano; Francisco Javier Medrano; Myung Hee Park; Sandro R Valentini
Journal:  Amino Acids       Date:  2009-12-03       Impact factor: 3.520

8.  Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].

Authors:  Yeon Sook Kim; Kee Ryeon Kang; Edith C Wolff; Jessica K Bell; Peter McPhie; Myung Hee Park
Journal:  J Biol Chem       Date:  2006-03-13       Impact factor: 5.157

9.  The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.

Authors:  Prajal H Patel; Mauro Costa-Mattioli; Karen L Schulze; Hugo J Bellen
Journal:  J Cell Biol       Date:  2009-06-22       Impact factor: 10.539

10.  Predicting the pathway involved in post-translational modification of elongation factor P in a subset of bacterial species.

Authors:  Marc Bailly; Valérie de Crécy-Lagard
Journal:  Biol Direct       Date:  2010-01-13       Impact factor: 4.540
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