Literature DB >> 3949725

A case of erythromycin-induced carbamazepine toxicity.

W H Berrettini.   

Abstract

A case of serious carbamazepine toxicity as a result of concomitant erythromycin therapy is presented. Carbamazepine competes with erythromycin for metabolism by hepatic microsomal enzymes, resulting in decreased clearance of carbamazepine. Carbamazepine drug interactions will become increasingly important to psychiatrists as this anticonvulsant becomes more widely used to treat affective disorders.

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Year:  1986        PMID： 3949725

Source DB:  PubMed          Journal:  J Clin Psychiatry        ISSN： 0160-6689            Impact factor:   4.384


  6 in total

1.  Interactions Between Antiepileptic and Antibiotic Drugs: A Systematic Review and Meta-Analysis with Dosing Implications.

Authors:  Carla Carnovale; Marco Pozzi; Faizan Mazhar; Giulia Mosini; Marta Gentili; Gabriëlla G A M Peeters; Emilio Clementi; Sonia Radice
Journal:  Clin Pharmacokinet       Date:  2019-07       Impact factor: 6.447

Review 2.  Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition.

Authors:  G K Dresser; J D Spence; D G Bailey
Journal:  Clin Pharmacokinet       Date:  2000-01       Impact factor: 6.447

Review 3.  Macrolide antibacterials. Drug interactions of clinical significance.

Authors:  N A von Rosensteil; D Adam
Journal:  Drug Saf       Date:  1995-08       Impact factor: 5.606

4.  Inhibition by erythromycin of the conversion of carbamazepine to its active 10,11-epoxide metabolite.

Authors:  N Barzaghi; G Gatti; F Crema; M Monteleone; C Amione; L Leone; E Perucca
Journal:  Br J Clin Pharmacol       Date:  1987-12       Impact factor: 4.335

Review 5.  Pharmacokinetic drug interactions of macrolides.

Authors:  P Periti; T Mazzei; E Mini; A Novelli
Journal:  Clin Pharmacokinet       Date:  1992-08       Impact factor: 6.447

Review 6.  Carbamazepine toxicity and poisoning. Incidence, clinical features and management.

Authors:  L Durelli; U Massazza; R Cavallo
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Mar-Apr
  6 in total

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