| Literature DB >> 3949474 |
L Takemoto, M Takehana, J Horwitz.
Abstract
Rabbit antisera have been made to the C-terminal octapeptide of bovine MIP26K (residues 256-263) and to an octapeptide near the C-terminus (residues 252-259). Use of these antisera in Western blot analysis of membrane from young vs old human lenses, and from cortex vs nucleus of old human lenses, suggest age-related covalent changes in the C-terminus of MIP26K. These age-related changes in anti-256-263 and anti-252-259 sera can be mimicked by treatment of lens membrane with carboxypeptidase Y, suggesting the loss of 1-8 amino acid residues from the C-terminus of the 26,000 dalton form of MIP26K during aging of the normal human lens.Entities:
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Year: 1986 PMID： 3949474
Source DB: PubMed Journal: Invest Ophthalmol Vis Sci ISSN： 0146-0404 Impact factor: 4.799