Literature DB >> 3949240

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.

T J Mitchell, J M Ketley, S C Haslam, J Stephen, D W Burdon, D C Candy, R Daniel.   

Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

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Year:  1986        PMID： 3949240      PMCID： PMC1433160          DOI： 10.1136/gut.27.1.78

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  22 in total

1.  Histopathological effect of Clostridium perfringens enterotoxin in the rabbit ileum.

Authors:  J L McDonel; C L Duncan
Journal:  Infect Immun       Date:  1975-11       Impact factor: 3.441

2.  Cytotoxicity assay in antibiotic-associated colitis.

Authors:  T W Chang; M Lauermann; J G Bartlett
Journal:  J Infect Dis       Date:  1979-11       Impact factor: 5.226

3.  Experimental cholera. A canine model.

Authors:  R B Sack; C C Carpenter; R W Steenburg; N F Pierce
Journal:  Lancet       Date:  1966-07-23       Impact factor: 79.321

4.  Comparative effects of enterotoxins from Escherichia coli and Vibrio cholerae on rabbit and swine small intestine.

Authors:  H W Moon; S C Whipp; A L Baetz
Journal:  Lab Invest       Date:  1971-08       Impact factor: 5.662

5.  Small bowel morphology in experimental canine cholera. A light and electron microscopic study.

Authors:  H L Elliott; C C Carpenter; R B Sack; J H Yardley
Journal:  Lab Invest       Date:  1970-02       Impact factor: 5.662

6.  Identification of Clostridium difficile as a cause of pseudomembranous colitis.

Authors:  R H George; J M Symonds; F Dimock; J D Brown; Y Arabi; N Shinagawa; M R Keighley; J Alexander-Williams; D W Burdon
Journal:  Br Med J       Date:  1978-03-18

7.  Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.

Authors:  J G Bartlett; A B Onderdonk; R L Cisneros; D L Kasper
Journal:  J Infect Dis       Date:  1977-11       Impact factor: 5.226

8.  Effect of enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae type 1 on fluid and electrolyte transport in the colon.

Authors:  M Donowitz; H J Binder
Journal:  J Infect Dis       Date:  1976-08       Impact factor: 5.226

9.  Comparison of two toxins produced by Clostridium difficile.

Authors:  N S Taylor; G M Thorne; J G Bartlett
Journal:  Infect Immun       Date:  1981-12       Impact factor: 3.441

10.  Differences in the response of rabbit small intestine to heat-labile and heat-stable enterotoxins of Escherichia coli.

Authors:  D G Evans; D J Evans; N F Pierce
Journal:  Infect Immun       Date:  1973-06       Impact factor: 3.441
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  49 in total

1.  Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis.

Authors:  Jun Huang; Ciarán P Kelly; Kyriaki Bakirtzi; Javier A Villafuerte Gálvez; Dena Lyras; Steven J Mileto; Sarah Larcombe; Hua Xu; Xiaotong Yang; Kelsey S Shields; Weishu Zhu; Yi Zhang; Jeffrey D Goldsmith; Ishan J Patel; Joshua Hansen; Meijin Huang; Seppo Yla-Herttuala; Alan C Moss; Daniel Paredes-Sabja; Charalabos Pothoulakis; Yatrik M Shah; Jianping Wang; Xinhua Chen
Journal:  Nat Microbiol       Date:  2018-12-03       Impact factor: 17.745

2.  The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B.

Authors:  M H Souza; A A Melo-Filho; M F Rocha; D M Lyerly; F Q Cunha; A A Lima; R A Ribeiro
Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

3.  Structural determinants of Clostridium difficile toxin A glucosyltransferase activity.

Authors:  Rory N Pruitt; Nicole M Chumbler; Stacey A Rutherford; Melissa A Farrow; David B Friedman; Ben Spiller; D Borden Lacy
Journal:  J Biol Chem       Date:  2012-01-20       Impact factor: 5.157

4.  Rabbit sucrase-isomaltase contains a functional intestinal receptor for Clostridium difficile toxin A.

Authors:  C Pothoulakis; R J Gilbert; C Cladaras; I Castagliuolo; G Semenza; Y Hitti; J S Montcrief; J Linevsky; C P Kelly; S Nikulasson; H P Desai; T D Wilkins; J T LaMont
Journal:  J Clin Invest       Date:  1996-08-01       Impact factor: 14.808

5.  A mixture of functionally oligoclonal humanized monoclonal antibodies that neutralize Clostridium difficile TcdA and TcdB with high levels of in vitro potency shows in vivo protection in a hamster infection model.

Authors:  Nicola L Davies; Joanne E Compson; Brendon Mackenzie; Victoria L O'Dowd; Amanda K F Oxbrow; James T Heads; Alison Turner; Kaushik Sarkar; Sarah L Dugdale; Mark Jairaj; Louis Christodoulou; David E O Knight; Amanda S Cross; Karine J M Hervé; Kerry L Tyson; Hanna Hailu; Carl B Doyle; Mark Ellis; Marco Kriek; Matthew Cox; Matthew J T Page; Adrian R Moore; Daniel J Lightwood; David P Humphreys
Journal:  Clin Vaccine Immunol       Date:  2013-01-16

6.  Clostridium difficile toxin A-induced microvascular dysfunction. Role of histamine.

Authors:  I Kurose; C Pothoulakis; J T LaMont; D C Anderson; J C Paulson; M Miyasaka; R Wolf; D N Granger
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

Review 7.  Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen.

Authors:  Milena M Awad; Priscilla A Johanesen; Glen P Carter; Edward Rose; Dena Lyras
Journal:  Gut Microbes       Date:  2014

8.  Evaluation of formalin-inactivated Clostridium difficile vaccines administered by parenteral and mucosal routes of immunization in hamsters.

Authors:  J F Torres; D M Lyerly; J E Hill; T P Monath
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

9.  Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection.

Authors:  M Warny; J P Vaerman; V Avesani; M Delmée
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

10.  CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.

Authors:  C Pothoulakis; I Castagliuolo; J T LaMont; A Jaffer; J C O'Keane; R M Snider; S E Leeman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205
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