Literature DB >> 3949004

Binding of transferrin-iron by adriamycin at acidic pH.

E J Demant, N Nørskov-Lauritsen.   

Abstract

It is shown that adriamycin is able to chelate iron released from iron-loaded serum transferrin in the pH range from 6.5-4.1. The kinetics of iron transfer to free adriamycin and to adriamycin covalently attached to the transferrin has been determined. The results show that adriamycin, if introduced into intracellular acidic compartments, could function as acceptor for transferrin-iron.

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Year:  1986        PMID： 3949004     DOI： 10.1016/0014-5793(86)80271-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  The interaction of Fe(III), adriamycin and daunomycin with nucleotides and DNA and their effects on cell growth of fibroblasts (NIH-3T3).

Authors:  I Di Liegro; A Cestelli; B F Matzanke; E Bill; A X Trautwein
Journal:  Biometals       Date:  1996-04       Impact factor: 2.949

2.  Formation of adriamycin--DNA adducts in vitro.

Authors:  C Cullinane; S M Cutts; A van Rosmalen; D R Phillips
Journal:  Nucleic Acids Res       Date:  1994-06-25       Impact factor: 16.971

3.  The removal of metal ions from transferrin, ferritin and ceruloplasmin by the cardioprotective agent ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] and its hydrolysis product ADR-925.

Authors:  B B Hasinoff; S V Kala
Journal:  Agents Actions       Date:  1993-05

4.  Inhibition and inactivation of NADH-cytochrome c reductase activity of bovine heart submitochondrial particles by the iron(III)-adriamycin complex.

Authors:  B B Hasinoff
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

5.  The iron(III)-adriamycin complex inhibits cytochrome c oxidase before its inactivation.

Authors:  B B Hasinoff; J P Davey
Journal:  Biochem J       Date:  1988-03-15       Impact factor: 3.857
  5 in total

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