Literature DB >> 3948967

Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland.

I A Lüthy, R S Calandra.   

Abstract

Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 10(8) M-1, only 10 times lower than the association constant for estradiol.

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Year:  1986        PMID： 3948967     DOI： 10.1007/bf01952433

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

1.  Relation of the ovary to adrenal corticosterone production and adrenal enzyme activity in the rat.

Authors:  J I Kitay; M D Coyne; W Newsom; R Nelson
Journal:  Endocrinology       Date:  1965-11       Impact factor: 4.736

2.  Effect of ovariectomy on pituitary secretion of ACTH.

Authors:  M D Coyne; J I Kitay
Journal:  Endocrinology       Date:  1969-12       Impact factor: 4.736

3.  [Competitive inhibition. General and new linear relations].

Authors:  M Best-Belpomme; P Dessen
Journal:  Biochimie       Date:  1973       Impact factor: 4.079

4.  Effect of bromocriptine on gonadal ornithine decarboxylase in vitro.

Authors:  P G Shah; A R Sheth
Journal:  Experientia       Date:  1979-12-15

5.  Influence of sex and gonadectomy on sex steroid receptors in rat adrenal gland.

Authors:  R S Calandra; I Lüthy; L Finocchiaro; R C Terrab
Journal:  J Steroid Biochem       Date:  1980-11       Impact factor: 4.292

6.  Estrogen-binding protein in mouse and rat adrenal glands.

Authors:  R E Müller; H H Wotiz
Journal:  J Biol Chem       Date:  1978-02-10       Impact factor: 5.157

7.  Oestrogen receptors in the rat adrenal gland.

Authors:  R S Calandra; O Naess; K Purvis; A Attramadal; O Djøseland; V Hansson
Journal:  J Steroid Biochem       Date:  1978-10       Impact factor: 4.292

8.  Estrogen receptor in rat adrenal gland.

Authors:  G B Cutler; K M Barnes; M A Sauer; D L Loriaux
Journal:  Endocrinology       Date:  1978-01       Impact factor: 4.736

9.  Effects of prolactin, bromocriptine and sulpiride on estrogen and lactogenic receptors in the rat adrenal gland.

Authors:  I A Lüthy; V A Chiauzzi; E H Charreau; R S Calandra
Journal:  Acta Physiol Pharmacol Latinoam       Date:  1984

10.  High-affinity binding of oestradiol-17beta by cytosols from testis interstitial tissue, pituitary, adrenal, liver and accessory sex glands of the male rat.

Authors:  W M van Beurden-Lamers; A O Brinkmann; E Mulder; H J van der Molen
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857
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