Literature DB >> 3946421

Polymorphisms of mitochondrially encoded proteins.

N B Spinner, M C King.   

Abstract

Polymorphisms of mitochondrially encoded proteins can be detected in human lymphocytes by sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Using an SDS-polyacrylamide 8 M urea system, 17 mitochondrially encoded proteins are distinguishable. Three of these (ME-6, ME-8, and ME-17) were polymorphic among 92 individuals screened, and these polymorphisms are reported here for the first time. With SDS-polyacrylamide electrophoresis without urea, 18 mitochondrial proteins are detectable. One of these (MV-1) varied in two of 31 individuals tested. This polymorphism has been identified previously in HeLa cells. Maternal inheritance of the ME-8 polymorphism was demonstrated by three informative families.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3946421      PMCID： PMC1684748     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  35 in total

1.  Familial "mitochondrial" myopathy. A myopathy associated with disordered oxidative metabolism in muscle fibres. 1. Clinical, electrophysiological and pathological findings.

Authors:  P Hudgson; W G Bradley; M Jenkison
Journal:  J Neurol Sci       Date:  1972-07       Impact factor: 3.181

2.  Leber's optic atrophy, a possible example of maternal inheritance.

Authors:  R P Erickson
Journal:  Am J Hum Genet       Date:  1972-05       Impact factor: 11.025

3.  Differential effects of chloramphenicol on the growth and respiration of mammalian cells.

Authors:  F C Firkin; A W Linnane
Journal:  Biochem Biophys Res Commun       Date:  1968-08-13       Impact factor: 3.575

4.  Mitochondrial protein synthesis: resistance to emetine and response to RNA synthesis inhibitors.

Authors:  S Perlman; S Penman
Journal:  Biochem Biophys Res Commun       Date:  1970-08-24       Impact factor: 3.575

5.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors:  K Weber; M Osborn
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

6.  Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

Authors:  A Chomyn; P Mariottini; M W Cleeter; C I Ragan; A Matsuno-Yagi; Y Hatefi; R F Doolittle; G Attardi
Journal:  Nature       Date:  1985 Apr 18-24       Impact factor: 49.962

7.  Polymorphic sites and the mechanism of evolution in human mitochondrial DNA.

Authors:  R L Cann; W M Brown; A C Wilson
Journal:  Genetics       Date:  1984-03       Impact factor: 4.562

8.  Differences in the products of mitochondrial protein synthesis in vivo in Human and mouse cells and their potential use as markers for the mitochondrial genome in human--mouse somatic cell hybrids.

Authors:  A Jeffreys; I Craig
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857

9.  Radiation of human mitochondria DNA types analyzed by restriction endonuclease cleavage patterns.

Authors:  M J Johnson; D C Wallace; S D Ferris; M C Rattazzi; L L Cavalli-Sforza
Journal:  J Mol Evol       Date:  1983       Impact factor: 2.395

10.  Antibodies against synthetic peptides reveal that the unidentified reading frame A6L, overlapping the ATPase 6 gene, is expressed in human mitochondria.

Authors:  P Mariottini; A Chomyn; G Attardi; D Trovato; D D Strong; R F Doolittle
Journal:  Cell       Date:  1983-04       Impact factor: 41.582
View more
  2 in total

Review 1.  Biogenesis of mitochondria and genetics of mitochondrial defects.

Authors:  A M Kroon; C Van den Bogert
Journal:  J Inherit Metab Dis       Date:  1987       Impact factor: 4.982

2.  Maternal modulation of the inheritable meiosis I error Dipl I in mouse oocytes is associated with the type of mitochondrial DNA.

Authors:  F Beermann; E Hummler; U Franke; I Hansmann
Journal:  Hum Genet       Date:  1988-08       Impact factor: 4.132
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.