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Literature DB >> 3945232

DNA degradation after interaction of cis- and trans-diamminedichloroplatinum (II) with calf thymus nuclei.

Abstract

DNA samples isolated from control nuclei and nuclei treated by cis- and trans-diamminedichloroplatinum (DDP) were analyzed by gel electrophoresis. There were no changes in Mr when DNA isolated from nuclei treated with trans-DDP was analyzed. Scans of DNA isolated from nuclei treated with cis-DDP revealed significant changes in Mr. This DNA bears, however, no signs of regular fragmentation. The possible involvement of endonuclease activity in the degradation process is discussed.

Entities: Chemical Species

Mesh：

Substances：
transplatin
DNA
Cisplatin

Year: 1986 PMID： 3945232 DOI： 10.1007/bf00417591

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

11 in total

1. The mechanism of action of antitumor platinum compounds.

Authors: J J Roberts; A J Thomson
Journal: Prog Nucleic Acid Res Mol Biol Date: 1979

2. The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.

Authors: U E Loening
Journal: Biochem J Date: 1967-01 Impact factor: 3.857

3. Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II).

Authors: A Eastman
Journal: Biochemistry Date: 1983-08-02 Impact factor: 3.162

4. On the degradation of chromatin to nucleosomes in the thymocytes of X-irradiated mice.

Authors: J Matyásová; M Skalka; M Cejková
Journal: Folia Biol (Praha) Date: 1984 Impact factor: 0.906

Review 5. Antitumor activity of platinum complexes.

Authors: J Drobník
Journal: Cancer Chemother Pharmacol Date: 1983 Impact factor: 3.333

6. Isolation of the products resulting from the reaction of cis and trans diaminedichloroplatinum [II] with DNA and chromatin on the Dowex 50 W column.

Authors: R Oliński; Z Walter
Journal: Z Naturforsch C Biosci Date: 1984 Nov-Dec

DNA degradation after interaction of cis- and trans-diamminedichloroplatinum (II) with calf thymus nuclei.

1. The mechanism of action of antitumor platinum compounds.

2. The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.

3. Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II).

4. On the degradation of chromatin to nucleosomes in the thymocytes of X-irradiated mice.

Review 5. Antitumor activity of platinum complexes.

6. Isolation of the products resulting from the reaction of cis and trans diaminedichloroplatinum [II] with DNA and chromatin on the Dowex 50 W column.

7. Mechanisms of cisplatin (cis-diamminodichloroplatinum II)-induced cytotoxicity and genotoxicity in yeast.

8. Viscosity, nicking, thermal and alkaline denaturation studies on three classes of DNA-platinum complex.

9. Alteration in the nucleosome and chromatin structures upon interaction with platinum coordination complexes.

10. The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G.

1. Evidence for lack of mitochondrial DNA repair following cis-dichlorodiammineplatinum treatment.