| Literature DB >> 3945166 |
S Albouz, F Le Saux, D Wenger, J J Hauw, N Baumann.
Abstract
Phenothiazines and tricyclic antidepressants, when added to culture medium, gave rise in several types of cells (C6 rat glioma cells and human fibroblasts), to a decrease in lysosomal sphingomyelinase activity. The effect of chlorpromazine and desipramine was dose dependent, and was observed after 3 hours of incubation with the drugs at concentrations ranging between 1 and 10 microM. In C6 glioma cell cultures, the decrease in sphingomyelinase activity was related to the clinical effectiveness of phenothiazines, tricyclic antidepressants and derivatives. Incorporation of (choline-14C) sphingomyelin showed that the metabolic pathway implying the synthesis of phosphatidylcholine from the hydrolysis of sphingomyelin and/or transfer of phosphorylcholine to phosphatidylcholine was also partially reduced.Entities:
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Year: 1986 PMID： 3945166 DOI： 10.1016/0024-3205(86)90083-4
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037